Pressure dependence of subharmonic signals from contrast microbubbles
Pressure dependence of subharmonic signals from contrast microbubbles
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DOI：
10.1016/s0301-5629(98)00163-x
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发表时间：
1999-02-01
影响因子：
2.9
通讯作者：
Goldberg, BB
中科院分区：
文献类型：
--
作者：
Shi, WT;Forsberg, F;Goldberg, BB
心脏腔和主要血管中的无创压力估计将为临床医生提供评估患有心脏和血管疾病的患者的有价值的工具。一些基于微泡的超声造影剂特别适合于压力测量，因为它们的基本可压缩性使得微泡能够响应于压力的变化而在尺寸上显著变化。然后，在静脉注射造影剂后，压力变化应影响微泡的反射率。这已被证明与半乳糖为基础的造影剂使用2.0 MHz的超声纯音脉冲。初步结果表明，在0-186 mmHg的压力范围内，在最佳声学设置下，散射信号的次谐波幅度降低了10 dB，一次和二次谐波幅度降低了不到3 dB。次谐波幅度与静水压力之间的良好相关性表明，次谐波信号可用于压力变化的无创检测。(C)1999年世界医学和生物学超声联合会。
Noninvasive pressure estimation in heart cavities and in major vessels would provide clinicians with a valuable tool for assessing patients with heart and vascular diseases. Some microbubble-based ultrasound contrast agents are particularly well suited for pressure measurements because their substantial compressibility enables microbubbles to vary significantly in size in response to changes in pressure. Pressure changes should then affect reflectivity of microbubbles after intravenous injection of a contrast agent. This has been demonstrated with a galactose-based contrast agent using 2.0-MHz ultrasound tone bursts. Preliminary results indicate that, over the pressure range of 0-186 mmHg, the subharmonic amplitude of scattered signals decreases by as much as 10 dB under optimal acoustic settings and the first and second harmonic amplitudes decrease by less than 3 dB, An excellent correlation between the subharmonic amplitude and the hydrostatic pressure suggests that the subharmonic signal may be utilized for noninvasive detection of pressure changes. (C) 1999 World Federation for Ultrasound in Medicine & Biology.