Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis
Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis
复制标题
Periostin是嗜酸性慢性鼻窦炎的加重因素和预测生物标志物
DOI：
10.1016/j.alit.2022.08.006
复制
发表时间：
2023
影响因子：
6.8
通讯作者：
et al
中科院分区：
文献类型：
--
作者：
Sato T;Ohta N;et al
背景：嗜酸性粒细胞性慢性鼻窦炎（ECRS）患者对许多治疗方式反应不佳。据报道，鼻粘膜中骨膜蛋白的过量产生会导致息肉的形成。本研究检查了 ECRS 患者与非 ECRS 患者的骨膜蛋白水平。方法：59 名慢性鼻窦炎患者分为 ECRS 患者和非 ECRS 患者。我们比较了各组外周血嗜酸性粒细胞水平、血清骨膜素水平、组织病理学检查结果、临床和实验室检查结果、鼻部检查结果、日本难治性嗜酸性慢性鼻窦炎流行病学调查研究诊断评分与鼻息肉术后复发的关系。结果：在ECRS组中，外周血嗜酸性粒细胞水平与血清骨膜素水平呈正相关（r s=0.49，P< 0.01：斯皮尔曼等级相关系数）。采用ROC曲线分析评价ECRS组预测鼻息肉术后复发的血清骨膜素水平：曲线下面积（AUC）为0.95，敏感性为92%，特异性为100%；鼻息肉术后复发的血清骨膜素截止值为130 ng/ml。采用ROC曲线分析评价外周血嗜酸性粒细胞水平，AUC为0.73，敏感性为69.2%，特异性为85.0%；截止值为8.8%。结论：骨膜素与ECRS的病理生理学有关。在 ECRS 中，骨膜素被证明是比嗜酸性粒细胞更有用的生物标志物。 Periostin 被证明可能是 ECRS 病理严重程度和鼻息肉术后复发的重要生物标志物。
Background: Patients with eosinophilic chronic rhinosinusitis (ECRS) respond poorly to many treatment modalities. Overproduction of periostin in the nasal mucosa is reported to contribute to polyp formation. This study examined periostin levels in patients with ECRS in comparison with levels in patients with non-ECRS.Methods: Fifty-nine patients with chronic rhinosinusitis were grouped into those with ECRS and those with non-ECRS. We compared the relationships between peripheral blood eosinophil level, serum periostin level, histopathological findings, clinical and laboratory findings, nose findings, diagnostic score of the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study, and postoperative recurrence of nasal polyps in each group.Results: In the ECRS group, a positive correlation was found between peripheral blood eosinophil level and serum periostin level (r s= 0.49, P< 0.01: Spearman's rank correlation coefficient). ROC curve analysis was used to evaluate the serum periostin level that could predict postoperative recurrence of nasal polyps in the ECRS group: the area under the curve (AUC) was 0.95, sensitivity was 92%, and specificity was 100%; the serum periostin cutoff value for postoperative recurrence of nasal polyps was 130 ng/ml. In ROC curve analysis to evaluate peripheral blood eosinophil level, the AUC was 0.73, sensitivity was 69.2%, and specificity was 85.0%; the cutoff value was 8.8%.Conclusions: periostin was implicated in the pathophysiology of ECRS. Periostin shown to be a more useful biomarker than eosinophils in ECRS. Periostin was shown to likely be an important biomarker for pathological severity of ECRS and postoperative recurrence of nasal polyps.