Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology.
Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology.
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脑环氧化物七氯和其他有机氯化合物与路易病理学的关联。
DOI：
10.1002/mds.27594
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
White,LonR
中科院分区：
文献类型：
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作者：
Ross,GWebster;Abbott,RobertD;Petrovitch,Helen;Duda,JohnE;Tanner,CarolineM;Zarow,Chris;Uyehara-Lock,JaneH;Masaki,KamalH;Launer,LenoreJ;Studabaker,WilliamB;White,LonR
背景有机氯农药与帕金森病的风险增加有关。檀香山-亚洲老龄化研究的初步分析表明，环氧化七氯（一种在夏威夷广泛使用的有机氯农药的代谢物）可能特别重要。这是一个横截面分析，以评估协会的七氯环氧化物和其他有机氯化合物与路易病理学在扩大调查脑有机氯残留物从纵向檀香山-亚洲老龄化Study.MethodsOrganochlorines测定冷冻枕叶或颞叶在705大脑使用气相色谱质谱。Lewy病理学的鉴定使用苏木精和伊红和α-synuclein免疫化学染色切片从多个brain regions.ResultsThe Lewy病理学的患病率几乎是在七氯环氧化物的存在与不存在的两倍（30.1%vs16.3%，P < 0.001）。虽然与其他化合物的关联较弱，但六氯苯（P= 0.003）和α-氯苯甲醚（P= 0.007）也与路易氏病变有关。然而，大多数后一种关联是由于七氯环氧化物造成的混淆。调整七氯环氧化物后，两种化合物均与路易病理学无显著相关性。相比之下，在调整六氯苯（P= 0.013）或α-氯丹（P= 0.005）后，七氯环氧化物与路易病理学的关联仍然显着。结果是不变的情况下，PD和调整年龄和其他feature. ConclusionsOrganochloropesticides删除后与路易病理在大脑中的存在，即使排除PD情况下。虽然大多数关联是通过七氯环氧化物，但其他有机氯化合物的作用需要澄清。© 2018国际帕金森和运动障碍协会
BackgroundOrganochlorine pesticides are associated with an increased risk of Parkinson's disease. A preliminary analysis from the Honolulu‐Asia Aging Study suggested that heptachlor epoxide, a metabolite from an organochlorine pesticide extensively used in Hawaii, may be especially important. This was a cross sectional analysis to evaluate the association of heptachlor epoxide and other organochlorine compounds with Lewy pathology in an expanded survey of brain organochlorine residues from the longitudinal Honolulu‐Asia Aging Study.MethodsOrganochlorines were measured in frozen occipital or temporal lobes in 705 brains using gas chromatography with mass spectrometry. Lewy pathology was identified using hematoxylin and eosin‐ and α‐synuclein immunochemistry‐stained sections from multiple brain regions.ResultsThe prevalence of Lewy pathology was nearly doubled in the presence versus the absence of heptachlor epoxide (30.1% versus 16.3%,P< 0.001). Although associations with other compounds were weaker, hexachlorobenzene (P= 0.003) and α‐chlordane (P= 0.007) were also related to Lewy pathology. Most of the latter associations, however, were a result of confounding from heptachlor epoxide. Neither compound was significantly related to Lewy pathology after adjustment for heptachlor epoxide. In contrast, the association of heptachlor epoxide with Lewy pathology remained significant after adjustments for hexachlorobenzene (P= 0.013) or α‐chlordane (P= 0.005). Findings were unchanged after removal of cases of PD and adjustment for age and other characteristics.ConclusionsOrganochlorine pesticides are associated with the presence of Lewy pathology in the brain, even after exclusion of PD cases. Although most of the association is through heptachlor epoxide, the role of other organochlorine compounds is in need of clarification. © 2018 International Parkinson and Movement Disorder Society