Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function
Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function
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DOI：
10.1182/blood-2004-12-4855
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发表时间：
2005-07-15
期刊：
影响因子：
20.3
通讯作者：
Loréal, O
中科院分区：
文献类型：
--
作者：
Dètivaud, L;Nemeth, E;Loréal, O
铁调素是铁代谢的关键调节剂，由肝脏合成。铁调素与铁输出蛋白ferroportin结合，以调节铁从巨噬细胞、肝细胞和肠细胞释放到血浆中。我们分析了接受癌症肝脏手术或接受肝移植的患者的肝脏样本，并分析了临床参数与肝脏hepcidin mRNA和尿hepcidin浓度之间的相关性。尽管存在许多潜在的混杂影响，但尿铁调素浓度与肝铁调素mRNA浓度显著相关，表明尿中铁调素定量是评价铁调素表达的有效方法。此外，我们在人体中发现，铁调素水平与肝脏铁储存和血红蛋白水平相关，也可能受到肝功能障碍的影响。
Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes. We analyzed liver samples from patients undergoing hepatic surgery for cancer or receiving liver transplants and analyzed correlations between clinical parameters and liver hepcidin mRNA and urinary hepcidin concentrations. Despite the many potential confounding influences, urinary hepcidin concentrations significantly correlated with hepatic hepcidin mRNA concentrations, indicating that hepcidin quantification in urine is a valid approach to evaluate hepcidin expression. Moreover, we found in humans that hepcidin levels correlated with hepatic iron stores and hemoglobin levels and may also be affected by hepatic dysfunction.