Noncoding RNAs and RNA-binding proteins in diabetic wound healing
Noncoding RNAs and RNA-binding proteins in diabetic wound healing
复制标题
非编码 RNA 和 RNA 结合蛋白在糖尿病伤口愈合中的作用
DOI：
10.1016/j.bmcl.2021.128311
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发表时间：
2021
影响因子：
2.7
通讯作者：
Chen Gang
中科院分区：
文献类型：
--
作者：
Li Xue;Li Ning;Li Bingxin;Feng Yuan;Zhou Di;Chen Gang
伤口愈合不良是糖尿病患者常见的并发症。它经常导致顽固性感染和下肢截肢，并与心血管疾病的发病率和死亡率有关。NcRNAs可以调节基因的表达，是多种生理过程的重要调节因子。在此，我们总结了ncRNAs在糖尿病伤口愈合的关键阶段中的不同作用，包括炎症、血管生成、再上皮化和细胞外基质重塑。同时，还讨论了ncRNAs作为糖尿病患者伤口愈合新的治疗靶点的潜在用途。此外，我们还总结了RNA结合蛋白在皮肤修复过程中调节基因表达和信号通路中的作用，这可能为这种潜在的破坏性疾病的治疗干预提供机会。然而，到目前为止，关于这种基于ncRNAs的调节药物导致糖尿病患者基因表达显著变化的研究很少。我们已经汇编了一些可能能够调节ncRNAs的药物，这些ncRNAs可以显著调节糖尿病患者的基因表达。
Poor wound healing is a common complication in diabetic patients. It often leads to intractable infections and lower limb amputations and is associated with cardiovascular morbidity and mortality. NcRNAs, which can regulate gene expression, have emerged as important regulators of various physiological processes. Herein, we summarize the diverse roles of ncRNAs in the key stages of diabetic wound healing, including inflammation, angiogenesis, re-epithelialization, and extracellular matrix remodeling. Meanwhile, the potential use of ncRNAs as novel therapeutic targets for wound healing in diabetic patients is also discussed. In addition, we summarize the role of RNA-binding proteins (RBPs) in the regulation of gene expression and signaling pathways during skin repair, which may provide opportunities for therapeutic intervention for this potentially devastating disease. However, so far, research on the modulated drug based on ncRNAs that lead to significantly altered gene expression in diabetic patients is scarce. We have compiled some drugs that may be able to modulate ncRNAs, which significantly regulate the gene expression in diabetic patients.