Adherence to antiretroviral prophylaxis during early infancy in Latin America.
Adherence to antiretroviral prophylaxis during early infancy in Latin America.
复制标题
拉丁美洲婴儿早期坚持抗逆转录病毒预防。
DOI：
10.1016/j.bjid.2012.11.006
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
NISDILILACStudyTeam
中科院分区：
文献类型：
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作者：
Hofer,CristinaB;Harris,DRobert;Saavedra,MarizaC;Haberer,JessicaE;Romeiro,Juliana;Mussi-Pinhata,MarisaM;Stankievich,Erica;Gomes,IveteM;Kreitchmann,Regis;Read,JenniferS;NISDILILACStudyTeam
We assessed reported adherence to antiretroviral (ARV) prophylaxis by HIV-exposed infants followed in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) International Site Development Initiative (NISDI) Longitudinal Study in Latin American Countries (LILAC) protocol 1 through at least 6-12 weeks of life. LILAC is a prospective cohort study at sites in Argentina, Brazil, and Peru which enrolled in 2008 and 2009. Among infants enrolled at birth, the primary caregiver was interviewed at birth and at every infant visit regarding infant adherence to ARVs during the previous three days, timing of last dose missed of any prescribed ARV, and any problems or situations making it difficult for caregivers to give infants the prescribed ARV (s).Of the 385 infants prescribed ARVs at enrollment, percent adherence could be calculated for 312 infants (ie, those with at least two days of available adherence data). Of these 312 infants, 309 (99.0%) had perfect adherence; 99% received zidovudine. Reasons cited for not having perfect adherence were: the maternity nurse did not administer the ARV (s) to the infant (n= 1), the caregiver forgot to give the ARV (s)(n= 1), and nausea (n= 1). At the 6-12 week visit, 115 (30.6%) infants had a current prescription for ARVs. Percent adherence could be calculated for 97 infants at this visit, of whom 92 (94.8%) had perfect adherence. Caregivers of nine infants (8.0%) reported the last dose missed of any prescribed ARV was within the previous two weeks, six (5.3%) within the previous month, and two (1.8%) over a month ago. The remaining 96 caregivers (85.0%) reported no missed doses. Seventeen caregivers indicated difficulties in giving ARVs to the infants. Primary reasons cited were: the caregiver forgot to give the ARV (s)(n= 5), the infant was sleeping (n= 2), the caregiver ran out of medication (n= 2), and the caregiver misunderstood the prescription (n= 2). Given the high proportion of subjects reporting perfect adherence, formal analyses of factors associated with lack of adherence were not pursued.
