The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder
The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder
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COMT Val158Met 对患有和不患有注意力缺陷/多动障碍的儿童执行功能的不同影响
DOI：
10.1111/gbb.12270
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发表时间：
2016-02-01
影响因子：
2.5
通讯作者：
Qian, Q.
中科院分区：
文献类型：
--
作者：
Jin, J.;Liu, L.;Qian, Q.
患有注意力缺陷/多动障碍 (ADHD) 的儿童通常表现出执行功能 (EF) 缺陷，这主要由前额叶皮层 (PFC) 介导。儿茶酚-O-甲基转移酶 (COMT)、Val158Met (rs4680) 的功能多态性导致在 PFC 内观察到多巴胺降解的多态性差异。本研究旨在采用病例对照设计探讨 rs4680 对 EF 的影响。此外，考虑到EF的动态发育，我们还尝试研究这种遗传影响在发育过程中是否会发生变化。总共招募了 597 名 ADHD 儿童和 154 名未受影响的对照者。使用 Rey-Osterrieth 复杂图形测试 (RCFT)、轨迹制作测试 (TMT) 以及 Stroop 颜色和单词测试来评估 EF 的工作记忆、转移和抑制。使用协方差分析（ancova）来分析基因型和 EF 之间的关联。结果显示，基因型和 ADHD 诊断对 RCFT 表现有显着的交互作用（P
Children with attention-deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol-O-methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic differences in the degradation of dopamine within PFC. This study aimed to explore the effect of rs4680 on EF using case-control design. In addition, considering the dynamic development of EF, we also attempted to investigate whether this genetic influence changes during development or not. A total of 597 ADHD children and 154 unaffected controls were recruited. The EF was evaluated using Rey-Osterrieth complex figure test (RCFT), trail making test (TMT) and Stroop color and word test for working memory, shifting and inhibition. Association between genotype and EF was analyzed using analysis of covariance (ancova). The results showed significant interaction effect of genotype and ADHD diagnosis on RCFT performance (P