Diversion of blood flow from noncompliant to compliant vasculature in awake dogs: mechanical impact on right atrial pressure.
Diversion of blood flow from noncompliant to compliant vasculature in awake dogs: mechanical impact on right atrial pressure.
复制标题
清醒狗的血流从非顺应性脉管系统转向顺应性脉管系统：对右心房压力的机械影响。
DOI：
10.1152/ajpheart.00482.2005
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Sheriff,DonD
中科院分区：
文献类型：
--
作者：
Zidon,TereseM;Sheriff,DonD
The distribution of cardiac output between compliant vasculature (e.g., splanchnic organs and skin) and noncompliant vasculature (e.g., skeletal muscle) is proposed to constitute an important determinant of the amount of blood available to the heart (central blood volume and pressure). The aim here was to directly test the hypothesis that diversion of blood flow from a relatively noncompliant vasculature (muscle) to compliant vasculature (splanchnic organs and skin) acts to reduce right atrial pressure. The approach was to inflate an occluder cuff on the terminal aorta for 30 s in one of two modes of ventricular pacing in five awake dogs with atrioventricular block and autonomic blockade. In one trial, cardiac output was maintained constant, meaning cuff inflation caused a portion of terminal aortic flow (a noncompliant circulation) to be diverted to the splanchnic and skin circulations (compliant circulations). In the other trial, arterial pressure was maintained constant, meaning blood flow to these other regions did not change. The response of right atrial pressure (corrected for differences in arterial pressure between the two trials) fit our hypothesis, being lower when blood flow was diverted to compliant regions. We conclude that a small (4% of cardiac output) diversion of blood flow from a noncompliant region to a compliant region reduces right atrial pressure by 0.7 mmHg.
