Increased variability of axonal excitability in amyotrophic lateral sclerosis.
Increased variability of axonal excitability in amyotrophic lateral sclerosis.
复制标题
肌萎缩侧索硬化症中轴突兴奋性的变异性增加。
DOI：
10.1016/j.clinph.2013.02.117
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kaji R.
中科院分区：
文献类型：
--
作者：
Shibuta Y;Shimatani Y;Nodera H;Izumi Y;Kaji R.
肌萎缩侧索硬化症（ALS）的特征是运动神经元的兴奋性增加和轴突的不均匀损失。ALS神经纤维间的异质性可能显示了ALS兴奋性的变异性。方法对28例ALS患者和23例对照者进行了多种神经兴奋性测试，在不同的阈值水平下进行跟踪结果在正常对照组中，与高目标水平相比，低目标水平的兴奋性措施具有以下特点：更长的强度持续时间常数，去极化电流期间更大的阈值降低和更小的超极化电流的阈值增加。ALS患者的参数与对照组相比具有较低的振幅依赖性，表明轴突兴奋性的变异性。三名ALS患者表现出更大的目标振幅依赖性阈值变化阈值电紧张比对照组，表明选择性轴突hyperexitability.ConclusionssSome的ALS患者有可变的轴突兴奋性在不同的目标振幅，提示在低靶振幅水平的轴突中存在优先的超兴奋性。意义ALS运动轴突的可变膜电位可以通过记录不同靶振幅水平的兴奋性测试来评估。振幅水平。
ObjectiveAmyotrophic lateral sclerosis (ALS) is characterised by the increased excitability of motoneurons and heterogeneous loss of axons. The heterogeneous nature of the disease process among fibres may show variability of excitability in ALS.MethodsMultiple nerve excitability tests were performed in 28 ALS patients and 23 control subjects, by tracking at the varying threshold levels (10%, 20%, 40% and 60% of maximum amplitudes).ResultsIn normal controls, excitability measures at low target levels have the following characteristics compared to those at high target levels: longer strength–duration time constant, greater threshold reduction during depolarising currents and smaller threshold increase to hyperpolarising currents. ALS patients had less clear amplitude dependency of the parameters than the controls, indicating variability of axonal excitability. Three ALS patients demonstrated greater target-amplitude-dependent threshold changes in threshold electrotonus than controls, suggesting selective axonal hyperexcitability.ConclusionsSome of the ALS patients had variable axonal excitability at different target amplitudes, suggesting preferential hyperexcitability in the axons with low target amplitude levels.SignificanceVariable membrane potentials of motor axons in ALS may be assessed by recording excitability testing at different target amplitude levels.