Mapping candidate non-MHC susceptibility regions to multiple sclerosis
Mapping candidate non-MHC susceptibility regions to multiple sclerosis
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DOI：
10.1038/sj.gene.6364320
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发表时间：
2006-09-01
影响因子：
5
通讯作者：
Graham, C. A.
中科院分区：
文献类型：
--
作者：
Abdeen, H.;Heggarty, S.;Graham, C. A.
Understanding the genetic basis of multiple sclerosis ( MS) remains a major challenge, despite decades of intensive research. In order to identify candidate non-MHC susceptibility regions to MS, the results of whole genome screens for linkage or association and follow-up studies in 18 different populations were superimposed together in a combined genomic map. Analysis of this map led to the prediction of at least 38 potential susceptibility regions, each showing linkage and/or association in several populations. Among these, 17 regions were the most reproducibly reported in these studies, thus representing top predicted candidates for MS. This non-formal approach to meta-analysis demonstrated the ability to verify results and retrieve lost information in an association study. Assessment of the map in a Northern Irish refined screen (n=415 cases, n=490 controls) revealed association in 15 regions (P < 0.05), including 10 promising candidates on chromosomes 1p13, 2p13, 2q14, 3p23, 7q21, 13q14, 15q13, 17p13, 18q21 and 20p12 (P < 0.0025). Seven of these regions were previously overlooked in the Northern Irish whole genome association study. Collating results from numerous studies, this draft map represents a tool that should facilitate the analysis of the genetic backgrounds of MS in many populations.
