Maternal stress and T-cell differentiation of the developing immune system: Possible implications for the development of asthma and atopy
Maternal stress and T-cell differentiation of the developing immune system: Possible implications for the development of asthma and atopy
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DOI：
10.1067/mai.2002.124776
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发表时间：
2002-06-01
影响因子：
14.2
通讯作者：
von Hertzen, LC
中科院分区：
文献类型：
--
作者：
von Hertzen, LC
哮喘和特应性疾病的患病率不断增加--尽管治疗有所改进，对疾病的许多方面也有了更多的了解--引起了越来越多的关注。越来越多的证据表明，特应性疾病的增加在很大程度上是由环境和生活方式因素造成的，在许多研究中，缺乏系统性儿童感染已成为一个主要因素。除了目前的高卫生标准和缺乏或罕见这种感染之外，还可能涉及我们当今生活的另一个特征因素。本文简要概述了母体应激持续过度分泌皮质醇可能会影响发育中的免疫系统，特别是T(H)1/T(H)2细胞分化，并进一步增加遗传易感性个体的哮喘和特应性。根据目前的知识，对这一假设进行了批判性的评估。
The constant increase in asthma and atopy prevalences-despite improved treatment and knowledge of many aspects of the diseases-has raised growing concern. Accumulating evidence suggests that these increases in atopic diseases are largely attributable to environmental and lifestyle factors, and the lack of systemic childhood infections has in many studies emerged as a major factor. In addition to current high standards of hygiene and the lack or scarcity of such infections, another factor characteristic of our present-day lives could be involved. This review briefly outlines the possibility that prolonged maternal stress associated with sustained excessive cortisol secretion could affect the developing immune system-especially T(H)1/T(H)2 cell differentiation-and further increase the susceptibility to asthma and atopy in genetically predisposed individuals. This hypothesis is critically evaluated in the light of current knowledge.