Age and experience-dependent representational reorganization during spatial learning.
Age and experience-dependent representational reorganization during spatial learning.
复制标题
空间学习过程中年龄和经验相关的表征重组。
DOI：
10.1016/s0197-4580(97)00150-4
复制
发表时间：
1997
影响因子：
4.2
通讯作者：
Kalyani,A
中科院分区：
文献类型：
--
作者：
Mizumori,SJ;Kalyani,A
以前，我们发现，老年大鼠表现出显着增强海马CA1位置细胞的空间特异性，以及减少门位置细胞的空间特异性，在渐近线性能的空间记忆任务。因为这样的年龄效应没有观察到动物进行非空间任务时，本研究测试的假设，即在记忆和非记忆测试中观察到的空间选择性的不同模式反映了空间表征的重新分配，发生在不断变化的任务需求。在本实验中，在动物熟悉测试环境和运动要求的性能上的径向迷宫，CA1和门位置细胞被记录，因为他们学会了空间记忆任务。CA1位置细胞记录未受损的老，但没有受损的老或年轻，动物变得更加空间选择性的动物学习的任务。两个年龄组的肺门空间选择性与选择准确性没有显著相关。这些数据支持的假设，至少一个亚群的老年大鼠可能受益于重组的空间表示，以这样一种方式，正常的年龄相关的空间学习缺陷被削弱。
Previously, we found that aged rats showed a significant enhancement of hippocampal CA1 place cell spatial specificity, as well as a reduction of hilar place cell spatial specificity, during asymptote performance of a spatial memory task. Because such an age effect was not observed when animals performed a nonspatial task, the present study tested the hypothesis that the different patterns of spatial selectivity observed in memory and nonmemory tests reflected a redistribution of spatial representations that occurred in response to changing task demands. In the present experiment, after animals became familiar with the test environment and motor demands of performance on a radial maze, CA1 and hilar place cells were recorded as they learned a spatial memory task. CA1 place cells recorded from unimpaired old, but not impaired old or young, animals became more spatially selective as animals learned the task. Hilar spatial selectivity for both age groups was not significantly related to choice accuracy. These data support the hypothesis that at least a subpopulation of aged rats may benefit from reorganization of spatial representations in such a way that the normal age-related spatial learning deficit is attenuated.