Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression
Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression
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DOI：
10.1038/tp.2017.116
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发表时间：
2017-06-06
影响因子：
6.8
通讯作者：
Aziz, N. A.
中科院分区：
文献类型：
--
作者：
Gardiner, S. L.;van Belzen, M. J.;Aziz, N. A.
抑郁症是世界范围内最普遍和最令人衰弱的精神疾病之一。最近，我们发现亨廷顿基因（HTT）中相对较短和相对较长的胞嘧啶-腺嘌呤-鸟嘌呤（CAG）重复序列与终身抑郁症的风险增加有关。然而，在何种程度上CAG重复长度的变化在其他八个多聚谷氨酰胺疾病相关基因（PDAGs）与抑郁症仍然是未知的。我们确定了CAG重复大小ATXN 1，ATXN 2，ATXN 3，CACNA 1A，ATXN 7，TBP，ATN 1和AR在两个特征良好的荷兰队列-荷兰抑郁症和焦虑症研究和荷兰老年人抑郁症研究-包括2165抑郁症和1058非抑郁症的个人，年龄在18-93岁。PDAG CAG重复序列大小与抑郁风险之间的关联通过二元逻辑回归进行评估。我们发现，与年龄>10岁的受试者相比，年龄>10岁的受试者终生抑郁的比值比（OR）显著更高。
Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine-adenine-guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts-the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons-including 2165 depressed and 1058 non-depressed individuals-aged 18-93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with