NEUROPEPTIDE Y-IMMUNOREACTIVE, TYROSINE HYDROXYLASE-IMMUNOREACTIVE AND VASOACTIVE INTESTINAL POLYPEPTIDE-IMMUNOREACTIVE NERVES IN BONE AND SURROUNDING TISSUES
NEUROPEPTIDE Y-IMMUNOREACTIVE, TYROSINE HYDROXYLASE-IMMUNOREACTIVE AND VASOACTIVE INTESTINAL POLYPEPTIDE-IMMUNOREACTIVE NERVES IN BONE AND SURROUNDING TISSUES
复制标题
神经肽 Y 免疫反应性、酪氨酸羟化酶免疫反应性和血管活性肠多肽 - 骨和周围组织中的免疫反应性神经
DOI：
10.1016/0165-1838(88)90016-1
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发表时间：
1988-12-01
期刊：
影响因子：
--
通讯作者：
SCHULTZBERG, M
中科院分区：
文献类型：
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作者：
BJURHOLM, A;KREICBERGS, A;SCHULTZBERG, M
在大鼠骨及邻近组织中发现神经肽Y（NPY）、酪氨酸羟化酶（TH）和血管活性肠肽（VIP）免疫反应阳性神经纤维。NPY和TH阳性纤维的分布不同于VIP阳性纤维的分布。神经肽Y和TH-免疫反应纤维几乎只发现接近或内的血管壁，主要是在附近的骺板，但也在Bistmann运河。VIP阳性纤维主要存在于骨骺和骨膜，仅偶尔在血管周围。这项研究表明，骨和周围组织有去甲肾上腺素能神经和含肽神经的供应。这些神经的不同分布可能反映了骨生理学的局部调节中的特定作用，例如血流、骨形成或骨吸收。
Nerve fibers immunoreactive to neuropeptide Y (NPY), tyrosine hydroxylase (TH) and vasoactive intestinal polypeptide (VIP) were demonstrated in rat bone and adjacent tissues. The distribution of NPY- and TH-positive fibres differed from that of VIP-positive fibres. NPY- and TH-immunoreactive fibres were almost exclusively found close to or within the blood vessel walls, mostly in the vincinity of the epiphyseal plate, but also in the Volkmann canals. VIP-positive fibres were predominantly present in the epiphysis and periosteum and only occasionally around blood vessels. This study demonstrates that bone and surrounding tissues have a supply of both noradrenergic and peptide-containing nerves. The differential distribution of these nerves may reflect specific roles in the local regulation of bone physiology, such as blood flow, bone formation or resorption.