Assessment of Intratumoral and Peritumoral Computed Tomography Radiomics for Predicting Pathological Complete Response to Neoadjuvant Chemoradiation in Patients With Esophageal Squamous Cell Carcinoma
Assessment of Intratumoral and Peritumoral Computed Tomography Radiomics for Predicting Pathological Complete Response to Neoadjuvant Chemoradiation in Patients With Esophageal Squamous Cell Carcinoma
复制标题
评估食管鳞状细胞癌患者对新辅助放化疗的病理完全缓解的瘤内和瘤周计算机断层扫描放射组学
DOI：
10.1001/jamanetworkopen.2020.15927
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发表时间：
2020-09-10
影响因子：
13.8
通讯作者：
Vardhanabhuti, Varut
中科院分区：
文献类型：
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作者：
Hu, Yihuai;Xie, Chenyi;Vardhanabhuti, Varut
关键问题：从治疗前的计算机断层扫描图像中提取的瘤周放射组学特征能预测食管鳞癌患者新辅助化疗后的病理完全反应吗？在这项对2 31名患者的诊断性研究中，与仅使用瘤内放射组学特征(瘤内放射组学特征下的面积，0.730)相比，所开发的模型结合了瘤内和瘤周放射组学特征，实现了预测性能(接收者操作特征曲线下的面积，0.852)的改进。这意味着，瘤周放射组学可能为食管鳞癌的治疗反应评估提供额外的预测价值，从而有利于个体化的治疗策略。
Key Points Question Are peritumoral radiomics features extracted from pretreatment computed tomography images predictive of pathological complete response following neoadjuvant chemoradiation in patients with esophageal squamous cell carcinoma? Findings In this diagnostic study of 231 patients, the developed model integrating intratumoral and peritumoral radiomics features achieved improvement of predictive performance (area under the receiver operating characteristic curve, 0.852) compared with the conventionally constructed model merely using intratumoral radiomics features (area under the receiver operating characteristic curve, 0.730). Meaning Peritumoral radiomics may provide additional predictive value for treatment response estimation in esophageal squamous cell carcinoma and thus benefit individualized therapeutic strategies.