From the Selectedworks of Marcel Adam Just Cortical Activation and Synchronization during Sentence Comprehension in High-functioning Autism: Evidence of Underconnectivity Cortical Activation and Synchronization during Sentence Comprehension in High-functi
From the Selectedworks of Marcel Adam Just Cortical Activation and Synchronization during Sentence Comprehension in High-functioning Autism: Evidence of Underconnectivity Cortical Activation and Synchronization during Sentence Comprehension in High-functi
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M. Just;T. Keller;N. Minshew;V. Cherkassky
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作者：
M. Just;T. Keller;N. Minshew;V. Cherkassky
采用功能磁共振技术对一组高功能自闭症受试者在句子理解过程中的脑激活进行了测量，并与言语智商匹配的对照组进行了比较。这两个群体在两个关键语言区域的激活分布不同。自闭症组在Wernicke区(左侧额上回)产生的激活可靠地高于对照组，而在Broca‘s区(左额下回)产生的激活可靠地低于对照组。此外，自闭症患者不同参与皮质区域之间的功能连接，即激活时间序列的同步度或相关性，始终低于对照组参与者。这些发现表明，自闭症患者语言障碍的神经基础导致语言处理的大规模皮质网络中的信息整合和同步程度较低。本文从理论上阐述了自闭症中连接不足的神经生物学基础方面的发现。缩写：fMRI=功能性磁共振成像；DLPFC=前额叶背外侧皮质；LIFG=左额下回；LSTG=左后上中回；ROI=感兴趣区
The brain activation of a group of high-functioning autistic participants was measured using functional MRI during sentence comprehension and the results compared with those of a Verbal IQ-matched control group. The groups differed in the distribution of activation in two of the key language areas. The autism group produced reliably more activation than the control group in Wernicke's (left latero-superior temporal) area and reliably less activation than the control group in Broca's (left inferior frontal gyrus) area. Furthermore, the functional connectivity, i.e. the degree of synchronization or correlation of the time series of the activation, between the various participating cortical areas was consistently lower for the autistic than the control participants. These findings suggest that the neural basis of disordered language in autism entails a lower degree of information integration and synchronization across the large-scale cortical network for language processing. The article presents a theoretical account of the findings, related to neurobiological foundations of underconnectiv-ity in autism. Abbreviations: fMRI = functional magnetic resonance imaging; DLPFC = dorsolateral prefrontal cortex; LIFG = left inferior frontal gyrus; LSTG = left posterior superior and middle temporal gyrus; ROI = region of interest