Cellular immunity in Q fever: specific lymphocyte unresponsiveness in Q fever endocarditis.
Cellular immunity in Q fever: specific lymphocyte unresponsiveness in Q fever endocarditis.
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Q 热中的细胞免疫：Q 热心内膜炎中的特异性淋巴细胞无反应。
DOI：
10.1093/infdis/152.6.1283
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Goodwin,JS
中科院分区：
文献类型：
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作者：
Koster,FT;Williams,JC;Goodwin,JS
人感染伯氏立克次体可表现为急性流感样原发性Q热、亚急性肉芽肿性肝炎或慢性心内膜炎伴肝炎。为了研究持续感染是否与可能的免疫缺陷有关，我们检测了患者和对照组外周血单个核细胞中柯萨奇病毒特异性淋巴细胞增殖。所有4例心内膜炎患者的淋巴细胞对Coxiella抗原均无反应，对对照抗原的增殖正常。肝炎和原发性Q热与体外对Coxiella抗原的强烈反应有关。抑制淋巴细胞无反应性的部分介导的抗原非特异性，玻璃贴壁细胞。我们假设特异性T细胞无反应性是烧伤衣原体持续感染的一个重要因素，并提供体外淋巴细胞刺激作为一种更特异性的诊断试验，以区分Q热所致慢性肝炎患者的心内膜炎病例。
Human infection with the rickettsiaCoxiella burnetiipresents as actue influenza-like primary Q fever, subacute granulomatous hepatitis, or chronic endocarditis with hepatitis. To investigate whether persistent infection is associated with a possible immunologic defect, we tested lymphocyte proliferation specific forCoxiellain vitro in peripheral blood mononuclear cells from patients and controls. All four patients with endocarditis had profound lymphocyte unresponsiveness toCoxiellaantigens with normal proliferation to control antigens. Hepatitis and primary Q fever were associated with vigorous responses in vitro toCoxiellaantigens. Suppression of lymphocyte unresponsiveness was in part mediated by an antigen-nonspecific, glass-adherent cell. We hypothesize that specific T cell unresponsiveness is an important factor in persistent infection withC burnetiiand offer in vitro lymphocyte stimulation as a more specific diagnostic test to distinguish cases of endocarditis among those with chronic hepatitis due to Q fever.