Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges.
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges.
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DOI：
10.1080/17425247.2022.2135699
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发表时间：
2022-10
影响因子：
6.6
通讯作者：
Clark, Meredith R.
中科院分区：
文献类型：
--
作者：
Agrahari, Vivek;Anderson, Sharon M.;Peet, M. Melissa;Wong, Andrew P.;Singh, Onkar N.;Doncel, Gustavo F.;Clark, Meredith R.
关键词：
对每日口服暴露前预防措施(PrEP)的坚持程度较差或不一致，已成为有效预防艾滋病毒的关键障碍。强效长效(LA)抗逆转录病毒药物(ARV)的问世与控释技术的进步相结合，使LA ARV药物输送系统(DDS)能够提供延长的给药间隔，并克服了每天口服给药时药物依从性不佳的挑战。该综述讨论了LA PrEP领域的现状、最新进展和新兴技术，包括ARV前体药物修饰和新的DDS。讨论了技术挑战、知识差距、临床前测试考虑因素以及在LA HIV PrEP临床翻译和实施的背景下重要的未来方向。艾滋病毒预防领域的发展速度比以往任何时候都快，开发下一代洛杉矶艾滋病毒预防方案的门槛继续上升。在资源有限的环境中实施可行的LA PrEP产品的要求具有挑战性，需要在设计和测试有前途的新候选产品时进行积极的考虑和产品修改。如果成功翻译，安全、负担得起、高效并被最终用户和关键利益攸关方接受的下一代LA PrEP将为遏制艾滋病毒大流行提供巨大潜力。
Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP) has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting (LA) antiretrovirals (ARVs) in conjunction with advances in controlled release technologies has enabled LA ARV drug delivery systems (DDS) capable of providing extended dosing intervals and overcome the challenge of suboptimal drug adherence with daily oral dosing. This review discusses the current state of the LA PrEP field, recent advances, and emerging technologies, including ARV prodrug modifications and new DDS. Technological challenges, knowledge gaps, preclinical testing considerations, and future directions important in the context of clinical translation and implementation of LA HIV PrEP are discussed. The HIV prevention field is evolving faster than ever and the bar for developing next-generation LA HIV prevention options continues to rise. The requirements for viable LA PrEP products to be implemented in resource-limited settings are challenging, necessitating proactive consideration and product modifications during the design and testing of promising new candidates. If successfully translated, next-generation LA PrEP that are safe, affordable, highly effective, and accepted by both end-users and key stakeholders will offer significant potential to curb the HIV pandemic.
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DOI：
10.1080/15257770.2014.945649
发表时间：
2015
期刊：
Nucleosides, nucleotides & nucleic acids
影响因子：
--
作者：
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影响因子：
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作者：
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