Schizophrenia is a disorder of higher order hierarchical processing
Schizophrenia is a disorder of higher order hierarchical processing
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DOI：
10.1016/j.mehy.2008.12.039
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发表时间：
2009-06-01
影响因子：
4.7
通讯作者：
Kraus, Michael
中科院分区：
文献类型：
--
作者：
Krishnan, Ranga R.;Keefe, Richard;Kraus, Michael
精神分裂症是一种精神障碍，患者表现为幻听、偏执或奇怪的妄想，以及说话和思维混乱。它与严重的社会功能障碍有关。关于精神分裂症有很多假说。其中大多数集中在精神分裂症作为遗传异常的表现[Mulle JG。基因组结构变异与精神分裂症Curr精神病学代表2008：10(2)：171-7]，病毒[Fruntes V，Limosin F.，神经发育过程中的精神分裂症和病毒感染：发病模型？Med Sci Monit 2008；14(6)：RA71-7]，神经化学[例如，多巴胺(Lewis DA，Akil M.皮质多巴胺在精神分裂症中：尸检策略。精神病学杂志1997；31(2)：175-95)或神经递质之间的相互作用(Duncan GE，Sheitman BB，Lieberman JA.精神分裂症的病理生理学模型的综合观点。Brain res Brain Resv 1999；29(2)：250-)]或脑结构[Kotrla KJ，Weinberger博士在精神分裂症中的脑成像。Annu Rev Med 1995；46：113-22]起源。这些假设中的大多数都没有解释这些假定的原因如何或为什么导致精神分裂症的表现。我们认为，大脑的结构和功能与构成健康人类感知和思维基础的分层处理结构是兼容的。我们认为，上述类型的扰动会导致大脑对更高水平的知觉和分层时间处理的干扰，这构成了精神分裂症的核心缺陷。我们提出的证据表明，这个模型解释了精神分裂症的许多特征，并对精神分裂症做出了一系列预测。(C)2009爱思唯尔有限公司。保留所有权利。
Schizophrenia is a mental disorder in which the patient manifests with auditory hallucinations, paranoid or bizarre delusions, and disorganized speech and thinking. It is associated with significant social dysfunction. There are many hypotheses regarding schizophrenia. Most of these focus on schizophrenia as a manifestation of abnormalities from genetic [Mulle JG. Genomic structural variation and schizophrenia. Curr Psychiatry Rep 2008:10(2):171-7], viral [Fruntes V, Limosin F. Schizophrenia and viral infection during neurodevelopment: a pathogenesis model? Med Sci Monit 2008;14(6):RA71-7], neurochemical [e.g. dopamine (Lewis DA, Akil M. Cortical dopamine in schizophrenia: strategies for postmortem studies. J Psychiatr Res 1997;31(2):175-95) or interactions between neurotransmitters (Duncan GE, Sheitman BB, Lieberman JA. An integrated view of pathophysiological models of schizophrenia. Brain Res Brain Res Rev 1999;29(2):250-64)] or brain structural [Kotrla KJ, Weinberger DR. Brain imaging in schizophrenia. Annu Rev Med 1995;46:113-22] origins. Most of these hypotheses do not account for how or why these presumed causes lead to the manifestations of schizophrenia. We argue that brain structure and function is compatible with a hierarchical processing structure that forms the basis for perception and thought in healthy humans. We propose that perturbations of the types listed above lead to disruption of higher levels of perception and hierarchical temporal processing by the brain and that this constitutes the core deficit in schizophrenia.We present evidence that this model explains many of the features of schizophrenia and we make a series of predictions about schizophrenia. (C) 2009 Elsevier Ltd. All rights reserved.