Body mass predicts orbitofrontal activity during visual presentations of high-calorie foods
Body mass predicts orbitofrontal activity during visual presentations of high-calorie foods
复制标题
DOI：
10.1097/00001756-200505310-00016
复制
发表时间：
2005-05-31
期刊：
影响因子：
1.7
通讯作者：
Yurgelun-Todd, DA
中科院分区：
文献类型：
--
作者：
Killgore, WDS;Yurgelun-Todd, DA
对于体重正常的人，体重状况和奖励相关的大脑活动之间的关系知之甚少。我们将13名健康、体重正常的成年女性在观看高热量和低热量食物以及用餐相关餐具的图像时，通过功能性磁共振成像测量的眶额和前扣带皮层活动与体重指数相关联。体重指数与扣带回和眶额活动呈负相关，在高热量观看，在低热量观看，眶额活动呈负相关，并与非食用器皿呈现眶额活动呈正相关。随着身体质量的增加，大脑区域的活动减少，这些区域对于评估和修改学习的刺激-奖励关联很重要，这表明体重状况与眶额皮层对奖励食物图像的反应之间存在关系。NeuroReport 16：859-863（c）2005 Lippincott威廉姆斯和威尔金斯。
Little is known about the relationship between weight status and reward-related brain activity in normal weight humans. We correlated orbitofrontal and anterior cingulate cortex activity as measured by functional magnetic resonance imaging with body mass index in 13 healthy, normal-weight adult women as they viewed images of high-calorie and low-calorie foods, and dining-related utensils. Body mass index correlated negatively with both cingulate and orbitofrontal activity during high-calorie viewing, negatively with orbitofrontal activity during low-calorie viewing, and positively with orbitofrontal activity during presentations of nonedible utensils. With greater body mass, activity was reduced in brain regions important for evaluating and modifying learned stimulus-reward associations, suggesting a relationship between weight status and responsiveness of the orbitofrontal cortex to rewarding food images. NeuroReport 16:859-863 (c) 2005 Lippincott Williams & Wilkins.