CURRENT CONCEPTS - IMMUNOLOGY - MONOCYTES AND MACROPHAGES
CURRENT CONCEPTS - IMMUNOLOGY - MONOCYTES AND MACROPHAGES
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DOI：
10.1056/nejm198803243181205
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发表时间：
1988-03-24
影响因子：
158.5
通讯作者：
JOHNSTON, RB
中科院分区：
文献类型：
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作者：
JOHNSTON, RB
巨噬细胞通过在特异性免疫的发展过程中向淋巴细胞呈递抗原，并至少部分通过释放可溶性因子作为淋巴细胞的支持性“辅助”细胞，在免疫应答中发挥核心和重要作用。巨噬细胞还执行摄取和杀死入侵生物体的基本保护功能，并且正如最近发现的那样，它们释放大量参与宿主防御和炎症的因子。增加了那些谁研究巨噬细胞的兴奋是越来越多的了解这些细胞如何可以“激活”，从而更有效地发挥其保护作用。. . .
MACROPHAGES play a central and essential part in the immune response by presenting antigen to lymphocytes during the development of specific immunity and by serving as supportive, "accessory" cells to lymphocytes, at least partly by releasing soluble factors. Macrophages also carry out the fundamental protective functions of ingesting and killing invading organisms, and as has recently been discovered, they release an enormous number of factors involved in host defense and inflammation. Adding to the excitement of those who study macrophages is the increasing understanding of how these cells can be "activated" pharmacologically to carry out their protective role more effectively. . . .