HLA class II association with rheumatoid arthritis - Facts and interpretations
HLA class II association with rheumatoid arthritis - Facts and interpretations
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DOI：
10.1016/s0198-8859(00)00185-3
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发表时间：
2000-12-01
期刊：
影响因子：
2.7
通讯作者：
de Vries, RRP
中科院分区：
文献类型：
--
作者：
Zanelli, E;Breedveld, FC;de Vries, RRP
我们回顾了HLA II类与类风湿关节炎（RA）的相关文献。DQB 1、DQA 1和DRB 1等位基因间存在较强的连锁不平衡，难以评价各基因座的个体贡献。尽管如此，DQB 1 *03和DQB 1 *04与DQA 1 *03组合在对严重RA的易感性中的作用是强有力的，而DQB 1 *0501与DQA 1 *0101和DQB 1 *0104组合在对轻度形式的RA的易感性中的作用是弱的。然而，同样清楚的是，DRB 1 *0401在最严重形式的疾病的易感性中具有特殊作用，而其他DRB 1等位基因可能提供比例。我们想提出，在类风湿关节炎，在I型糖尿病，DQ和DR基因座有助于疾病的易感性。(C)美国组织相容性和免疫遗传学学会，2000年。出版社：Elsevier Science Inc.
We have reviewed the literature on the association of HLA class II with rheumatoid arthritis (RA). Strong linkage disequilibrium among DQB1, DQA1 and DRB1 alleles makes it difficult to evaluate the individual contribution of each locus. Nonetheless, there is a strong case for the role of DQB1*03 and *04 combined with DQA1*03 in susceptibility to severe RA while DQB1*0501 combined with DQA1*0101 and *0104 weakly predisposes ro a mild form of RA. However, it is also clear that DRB1*0401 has a particular role in predisposition to the most severe form of the disease while other DRB1 alleles might provide prorcction. We would like to propose that in RA, as in type I diabetes, both DQ and DR loci contribute to predisposition to the disease. (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.