SEASONAL-CHANGES IN MUCOSAL STRUCTURE AND FUNCTION IN GROUND-SQUIRREL INTESTINE
SEASONAL-CHANGES IN MUCOSAL STRUCTURE AND FUNCTION IN GROUND-SQUIRREL INTESTINE
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DOI：
10.1152/ajpregu.1990.259.2.r385
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发表时间：
1990-08-01
影响因子：
--
通讯作者：
CAREY, HV
中科院分区：
文献类型：
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作者：
CAREY, HV
在活跃和冬眠的地松鼠空肠中检查了粘膜结构和运输功能的季节性变化。粘膜湿重和蛋白质含量、绒毛高度和粘膜表面积在冬眠者中最低，春季增加，夏季达到峰值，秋季下降。在 7°C 下测试的冬眠组织中，在通量室中测量的跨上皮电参数以及净 Na+ 和 3-O-甲基葡萄糖 (3-OMG) 吸收量大大降低。 C 与在 37°C 下研究的冬眠者或活跃松鼠的组织进行比较。 C. 37°C。 C，所有松鼠组织中标准化为浆膜表面积的净 Na+ 和 3-OMG 吸收量相似。当对粘膜表面积进行归一化时，冬眠松鼠的吸收量大于春季或夏季松鼠的吸收量，但与秋季值没有显着差异。春季、夏季和秋季松鼠的粘膜区域吸收标准化相似。冬眠者中粘膜添加 D-葡萄糖或 L-丙氨酸引起的短路电流增加明显大于秋季松鼠。这些结果证明了圈养地松鼠粘膜结构和运输功能的季节性变化。增强冬眠组织在 37°C 下的区域特异性吸收。 C可能代表对冬眠期间发生的明显粘膜萎缩的代偿反应。
Seasonal variations in mucosal structure and transport function were examined in active and hibernating ground squirrel jejunum. Mucosal wet weight and protein content, villus height, and mucosal surface area were lowest in hibernators, increased in spring, peaked in summer, and declined in fall. Transepithelial electrical parameters and net Na+ and 3-O-methylglucose (3-OMG) absorption measured in flux chambers were greatly reduced in hibernator tissues tested at 7.degree. C compared with tissues from hibernators or active squirrels studied at 37.degree. C. At 37.degree. C, net Na+ and 3-OMG absorption normalized to serosal surface area was similar in tissues from all squirrels. When normalized to mucosal surface area, absorption in hibernators was greater than in spring or summer squirrels but was not significantly different from fall values. Absorption normalized to mucosal area was similar among spring, summer, and fall squirrels. Increases in short-circuit current evoked by mucosal addition of D-glucose or L-alanine were significantly greater in hibernators than in fall squirrels. These results demonstrate seasonal variations in mucosal structure and transport function in captive ground squirrels. Enhanced area-specific absorption in hibernator tissues at 37.degree. C may represent a compensatory response to pronounced mucosal atrophy that occurs during hibernation.