A PROSPECTIVE-STUDY OF VERTICAL TRANSMISSION OF HIV-2 IN BISSAU, GUINEA-BISSAU
A PROSPECTIVE-STUDY OF VERTICAL TRANSMISSION OF HIV-2 IN BISSAU, GUINEA-BISSAU
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DOI：
10.1097/00002030-199307000-00013
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发表时间：
1993-07-01
期刊：
影响因子：
3.8
通讯作者：
BIBERFELD, G
中科院分区：
文献类型：
--
作者：
ANDREASSON, PA;DIAS, F;BIBERFELD, G
目的：了解HIV-2垂直传播率及与HIV-2垂直传播感染相关的临床表现。设计：一项HIV-2血清阳性母亲的儿童HIV-2传播的前瞻性研究，并比较血清阳性母亲和血清阴性母亲的儿童的临床表现。环境：招募在几内亚比绍比绍国立医院分娩的妇女。通过家访跟进。对象与方法：对82例HIV-2血清阳性母亲的86例新生儿和102例HIV-2血清阴性母亲的102例新生儿进行临床随访和HIV血清学随访，直至儿童20月龄。结果：86例血清阳性母亲的患儿中，51例随访完整，22例死亡，13例因迁居失联。在102名血清阴性母亲的孩子中，63人有完整的随访，13人死亡，26人因居住地变化而失踪。在随访期结束时，51名血清阳性母亲的儿童中没有人有HIV-2感染的血清学证据。在临床症状出现频率上，研究组与对照组无显著差异。血清阳性母亲和血清阴性母亲的婴儿出生后第一年的死亡率差异无统计学意义（分别为80 / 13和94 / 11，P < 0.05，不包括失去随访的儿童）。血清阳性母亲的死亡儿童中只有3名和血清阴性母亲的死亡儿童中有1名有可能与艾滋病毒-2感染有关的任何症状（腹泻1个月）。结论：HIV-2的垂直传播是罕见的。
Objectives: To determine the vertical transmission rate of HIV-2 and clinical findings associated with vertically transmitted HIV-2 infection.Design: A prospective study of HIV-2 transmission in children of HIV-2-seropositive mothers, and a comparison of clinical findings between children of seropositive and seronegative mothers.Setting: Recruitment of women delivering at the national hospital in Bissau, Guinea-Bissau. Follow-up by home visits.Subjects and methods: Eighty-six newborns of 82 HIV-2-seropositive mothers and a control group of 102 newborns of HIV-seronegative mothers were followed-up clinically and by HIV serology until the children reached the age of 20 months.Results: Of the 86 children of seropositive mothers, 51 had a complete follow-up, 22 died and 13 were lost due to change of residence. Of the 102 children of seronegative mothers, 63 had a complete follow-up, 13 died and 26 were lost due to change of residence. None of 51 children of seropositive mothers had serological evidence of HIV-2 infection at the end of the follow-up period. There was no significant difference in the frequency of clinical symptoms between the children in the study group and the children in the control group. The mortality during the first year of life was not significantly different between the children of seropositive and seronegative mothers (13 out of 80 and 11 out of 94, respectively, P > 0.05, excluding children lost to follow-up). Only three of the dead children of seropositive mothers and one of the dead children of seronegative mothers had any symptoms that might be related to HIV-2 infection (diarrhoea >1 month). Conclusion: Vertical transmission of HIV-2 appears to be rare.