A distinct bacterial dysbiosis associated skin inflammation in ovine footrot.
A distinct bacterial dysbiosis associated skin inflammation in ovine footrot.
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DOI：
10.1038/srep45220
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发表时间：
2017-03-24
影响因子：
4.6
通讯作者：
Tötemeyer S
中科院分区：
文献类型：
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作者：
Maboni G;Blanchard A;Frosth S;Stewart C;Emes R;Tötemeyer S
绵羊蹄疾是一种由结节双歧杆菌引起的高度流行的细菌性疾病，其特征是蹄角与下面的皮肤分离。先天免疫分子和其他细菌群落在足步病变发展中的作用尚不清楚。这项研究表明，在足步舞样本中，IL-1β的高表达与结节吸虫的高负荷之间存在显著的相关性。对微生物种群的调查确定了不同疾病阶段的不同细菌种群，并取决于炎症程度。密螺旋体(34%)、支原体(29%)和卟啉单胞菌(15%)是与足步高度炎症相关的最丰富的属。相比之下，不动杆菌(25%)、棒状杆菌(17%)和黄杆菌(17%)是与健康足部高水平炎症相关的最丰富的属。这首次证明了与Footrot和高细胞因子表达相关的独特微生物群落。
Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma (29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.