The prevalence and features of the polycystic ovary syndrome in an unselected population
The prevalence and features of the polycystic ovary syndrome in an unselected population
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DOI：
10.1210/jc.2003-032046
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发表时间：
2004-06-01
影响因子：
5.8
通讯作者：
Yildiz, BO
中科院分区：
文献类型：
--
作者：
Azziz, R;Woods, KS;Yildiz, BO
尽管多囊卵巢综合征（PCOS）对公共卫生有潜在影响，但对其患病率的估计有限且不明确。1998年7月至1999年10月，400名绝经前妇女（18 - 45岁）在伯明翰的亚拉巴马大学寻求就业前体检（223名黑人，166名白色，11名其他种族）进行了研究。评估包括病史和体格检查、改良Ferriman-Gallwey多毛症评分、血清高雄激素血症、高泌乳素血症和21-羟化酶缺乏型非经典肾上腺增生筛查。多囊卵巢综合征的诊断依据是：1）排卵过少，2）高雄激素血症和/或多毛症（改良的Ferriman-Gallwey评分大于或等于6），3）排除相关疾病。在那些评估完成并指示PCOS的个体中确定了确诊的PCOS，并且当激素评估不完整或不可用时确定了可能的PCOS，但临床表型提示了该疾病。根据评估完成的相似受试者的结果，为可能患有PCOS的女性中PCOS的个体概率分配权重，并计算这些个体中产生的PCOS病例总数（即PCOS的个体概率x组中受试者总数）。我们人群中PCOS的累积患病率为6.6%（400例中的26.5例），包括完成评估的347名妇女中的15例受试者，其余受试者中的计算患病率为11.5例。黑人和白色妇女的PCOS患病率分别为8.0%和4.8%，差异无统计学意义。这些数据来自一个大的代表性的美国人口支持的概念，多囊卵巢综合征是最常见的内分泌异常的育龄妇女在美国。
Notwithstanding the potential public health impact of the polycystic ovary syndrome ( PCOS), estimates regarding its prevalence are limited and unclear. Between July 1998 and October 1999, 400 unselected consecutive premenopausal women ( 18 - 45 yr of age) seeking a preemployment physical at the University of Alabama at Birmingham were studied ( 223 Black, 166 White, and 11 of other races). Evaluation included a history and physical examination, a modified Ferriman-Gallwey hirsutism score, and serum screening for hyperandrogenemia, hyperprolactinemia, and 21-hydroxylase-deficient nonclassical adrenal hyperplasia. PCOS was diagnosed by the presence of the following: 1) oligoovulation, 2) hyperandrogenemia and/or hirsutism ( modified Ferriman-Gallwey score greater than or equal to 6), and 3) the exclusion of related disorders. Confirmed PCOS was established in those individuals whose evaluation was complete and indicative of PCOS, and possible PCOS was established when the hormonal evaluation was not complete or was unavailable, but the clinical phenotype was otherwise suggestive of the disorder. The individual probability of PCOS in women with possible PCOS was assigned a weight based on the findings in similar subjects whose evaluation was complete, and the total number of PCOS cases arising from these individuals was calculated (i.e. individual probability of PCOS x total number of subjects in the group). The cumulative prevalence of PCOS in our population was 6.6% (26.5 of 400), including 15 subjects among the 347 women completing their evaluation and a calculated prevalence of 11.5 subjects among the remainder. The prevalence rates of PCOS for Black and White women were 8.0 and 4.8%, respectively, not significantly different. These data from a large representative unselected population support the concept that PCOS is the most common endocrine abnormality of reproductive-aged women in the United States.