Noninvasive determination of blood constituents using an array of modulated laser diodes and a photoacoustic sensor head
Noninvasive determination of blood constituents using an array of modulated laser diodes and a photoacoustic sensor head
复制标题
使用调制激光二极管阵列和光声传感器头无创测定血液成分
DOI：
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发表时间：
1996
影响因子：
4.3
通讯作者：
R. Niessner
中科院分区：
文献类型：
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作者：
G. Spanner;R. Niessner
利用光声激光光谱技术，对血红蛋白和葡萄糖等血液成分进行无创测定是可行的。我们研究的目的是开发一种适用于糖尿病患者血糖浓度连续无创监测的传感器。为此目的，开发了一种光声传感器头，并通过光纤束耦合到在近红外区域发射各种波长的8个激光二极管阵列。采用特殊的调制方案，可以测量血糖浓度变化引起的全血吸收系数的微小变化。实现了70 mg/dl的分辨率，该值已经接近连续工作的葡萄糖传感器的临床要求。
Using photoacoustic laser spectroscopy, the noninvasive determination of blood constituents like hemoglobin and glucose is feasible. The aim of our investigations is the development of a sensor which is suitable for continuously noninvasive monitoring of blood glucose concentrations in diabetic patients. For this purpose a photoacoustic sensor head was developed and coupled via an optical fiber bundle to an array of 8 laser diodes emitting at various wavelengths in the near infrared region. Applying a special modulation scheme, the tiny changes of the absorption coefficient of whole blood caused by the variations of blood glucose concentrations could be measured. A resolution of 70 mg/dl was achieved, a value which is already close to the clinical requirements for a continuously working glucose sensor.