Prognostic significance of serum hepatocyte growth factor in clear cell renal cell carcinoma : comparison with serum vascular endothelial growth factor
Prognostic significance of serum hepatocyte growth factor in clear cell renal cell carcinoma : comparison with serum vascular endothelial growth factor
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DOI：
10.2152/jmi.55.106
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发表时间：
2008-02-01
影响因子：
0.7
通讯作者：
Kanayama, Hiro-Omi
中科院分区：
文献类型：
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作者：
Tanimoto, Shuji;Fukumori, Tomoharu;Kanayama, Hiro-Omi
目前还没有足够的血清预测生物标志物来识别肾癌(RCC)的活动性。我们研究了未经治疗的透明细胞肾癌患者血清肝细胞生长因子(HGF)和血清血管内皮生长因子(VEGF)水平与临床病理参数的关系。用双抗体夹心酶联免疫吸附试验检测了45例未经治疗的肾透明细胞癌患者和45例健康人血清中HGF和VEGF的水平。透明细胞肾癌患者血清肝细胞生长因子和血管内皮生长因子水平显著高于健康对照组：中位数分别为1070.7和728.3 pg/ml(P<0.05)。
No adequate serum predictive biomarker currently exists, which can identify the activity of renal cell carcinoma (RCC). We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. We measured serum levels of HGF and VEGF in 45 patients with untreated clear cell RCC and 45 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Patients with clear cell RCC had significantly higher serum HGF and VEGF concentrations than healthy subjects : median, 1070.7versus 728.3 pg/ml (p