Longitudinal impact of gender-affirming endocrine intervention on the mental health and well-being of transgender youths: preliminary results
Longitudinal impact of gender-affirming endocrine intervention on the mental health and well-being of transgender youths: preliminary results
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DOI：
10.1186/s13633-020-00078-2
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发表时间：
2020-04-30
期刊：
影响因子：
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通讯作者：
Wilson, Thomas A.
中科院分区：
文献类型：
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作者：
Achille, Christal;Taggart, Tenille;Wilson, Thomas A.
背景/目的与顺性同龄人相比，跨性别青少年抑郁和自杀意念的发生率较高。先前的研究表明，内分泌和/或手术干预与成年变性人的心理健康改善有关。我们研究了内分泌干预（青春期抑制和/或交叉性激素治疗）与跨性别青少年抑郁和生活质量评分之间的关系。方法每隔大约6个月，参与者在参与内分泌干预的同时完成抑郁和生活质量问卷。采用多元线性回归和残差评分来比较结果。结果2013 - 2018年间，50名内分泌干预新手（平均年龄16.2 + 2.2岁）完成了3波问卷调查。平均抑郁得分和自杀意念随时间下降，而平均生活质量得分随时间提高。在控制精神病药物和心理咨询的情况下，回归分析显示内分泌干预可以改善病情。这在男性对女性的参与者中具有重要意义。结论内分泌干预可改善美国跨性别青少年的心理健康状况。这种效应在男性对女性和女性对男性的年轻人中都有观察到，但在前者中表现得更强。
Background/aims Transgender youths experience high rates of depression and suicidal ideation compared to cisgender peers. Previous studies indicate that endocrine and/or surgical interventions are associated with improvements to mental health in adult transgender individuals. We examined the associations of endocrine intervention (puberty suppression and/or cross sex hormone therapy) with depression and quality of life scores over time in transgender youths. Methods At approximately 6-month intervals, participants completed depression and quality of life questionnaires while participating in endocrine intervention. Multiple linear regression and residualized change scores were used to compare outcomes. Results Between 2013 and 2018, 50 participants (mean age 16.2 + 2.2 yr) who were naive to endocrine intervention completed 3 waves of questionnaires. Mean depression scores and suicidal ideation decreased over time while mean quality of life scores improved over time. When controlling for psychiatric medications and engagement in counseling, regression analysis suggested improvement with endocrine intervention. This reached significance in male-to-female participants. Conclusion Endocrine intervention may improve mental health in transgender youths in the US. This effect was observed in both male-to-female and female-to-male youths, but appears stronger in the former.