RESPIRATORY FLUCTUATIONS IN PUPIL SIZE
RESPIRATORY FLUCTUATIONS IN PUPIL SIZE
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DOI：
10.1152/ajplegacy.1975.228.4.1094
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发表时间：
1975-01-01
影响因子：
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通讯作者：
BORGDORFF, P
中科院分区：
文献类型：
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作者：
BORGDORFF, P
研究人员测量了猫瞳孔大小的规律波动，并研究了这些波动的特性、神经通路和起源。在控制条件下，瞳孔运动的节律似乎要么锁定于中枢呼吸周期，要么锁定于人工通气周期。这些运动仅在轻度麻醉或镇静的猫中可见，但在警觉或深度麻醉（乙醚、氟烷或戊巴比妥）的猫中看不到。事实证明，这种波动与交感神经支配无关，但与副交感神经流出的变化有关。瞳孔振荡至少有两个来源：中枢呼吸活动和通过窦主动脉压力感受器调节瞳孔宽度的呼吸血压波动。作为第三个可能的因素，肺部运动本身不会调节瞳孔宽度，而传入肺迷走神经的电刺激却可以调节瞳孔宽度。因此该机械因素的作用尚不清楚。查阅相关文献表明，生物体内存在许多表现出呼吸振荡的现象。这些振荡似乎与呼吸瞳孔波动具有相同的起源。
Regular fluctuations in pupil size of the cat were measured and the properties, nervous pathways, and origin of these oscillations were investigated. The rhythm of pupil movements under control conditions appeared to be either locked to the central respiratory cycle or to the artificial ventilatory cycle. These movements were only seen in lightly anesthetized or tranquilized cats, but not in alert or deeply anesthetized cats (ether, halothane or pentobarbital). The fluctuations proved to be independent of sympathetic innervation but related to variations in parasympathetic outflow. At least two sources for pupil oscillations appeared to be involved: central respiratory activity and respiratory blood pressure fluctuations that modulated pupil width via sinoaortic baroreceptors. Lung movements per se, as a third possible factor, did not modulate pupil width, whereas electrical stimulation of the afferent lung vagi did; therefore the role of this mechanical factor is not clear. A review of the pertinent literature shows that in the organism there are many phenomena exhibiting respiratory oscillations. It seems likely that these oscillations have the same origin as the respiratory pupil fluctuations.