Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils.
Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils.
复制标题
DOI：
10.1002/prot.22832
复制
发表时间：
2010-12
影响因子：
2.9
通讯作者：
Guy, H. Robert
中科院分区：
文献类型：
--
作者：
Shafrir, Yinon;Durell, Stewart R.;Anishkin, Andriy;Guy, H. Robert
关键词：
Both soluble and membrane-bound pre-fibrillar assemblies of Abeta (Aβ) peptides have been associated with Alzheimer's disease (AD). The size and nature of theses assemblies vary greatly and are affected by many factors. Here we present models of soluble hexameric assemblies of Aβ42 and suggest how they can lead to larger assemblies and eventually to fibrils. The common element in most of these assemblies is a six-stranded β-barrel formed by the last third of Aβ42, which is composed of hydrophobic residues and glycines. The hydrophobic core β-barrels of the hexameric models are shielded from water by the N-terminus and central segments. These more hydrophilic segments were modeled to have either predominantly β or predominantly α secondary structure. Molecular dynamics simulations were performed to analyze stabilities of the models. The hexameric models were used as starting points from which larger soluble assemblies of 12 and 36 subunits were modeled. These models were developed to be consistent with numerous experimental results.
登录
查看更多内容
影响因子：
3.4
作者：
Brorsson, Ann-Christin;Bolognesi, Benedetta;Luheshi, Leila M.
通讯作者：
Luheshi, Leila M.
影响因子：
4.8
作者：
Curtain, CC;Ali, F;Barnham, KJ
通讯作者：
Barnham, KJ
DOI：
10.1073/pnas.1237107100
发表时间：
2003-05-27
影响因子：
11.1
作者：
Hoshi, M;Sato, M;Sato, K
通讯作者：
Sato, K
影响因子：
21.8
作者：
通讯作者：
--
影响因子：
5.3
作者：
Hartley, DM;Walsh, DM;Selkoe, DJ
通讯作者：
Selkoe, DJ