Crystal structures and antifungal activities of fluorine-containing thioureido complexes with nickel(II).
Crystal structures and antifungal activities of fluorine-containing thioureido complexes with nickel(II).
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含氟硫脲与镍(II)配合物的晶体结构和抗真菌活性
DOI：
10.3390/molecules181215737
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发表时间：
2013-12-17
期刊：
影响因子：
--
通讯作者：
Xie J
中科院分区：
文献类型：
--
作者：
Li C;Yang W;Liu H;Li M;Zhou W;Xie J
合成了n -2-氟苯甲酰哌啶-1-碳硫咪酯（L2−）、n -4-氟苯甲酰哌啶-1-碳硫咪酯（L3−）、n -2-氟苯甲酰啉-1-碳硫咪酯（L5−）和n -4-氟苯甲酰morpholin -1-碳硫咪酯（L6−）的Ni（II）配合物，并通过元素分析、FTIR和1H-NMR进行了表征。用x射线衍射测定了三种配体（HL2、HL3和HL6）和相应的Ni（II）配合物([Ni(L2)2]、[Ni（L3)2]和[Ni(L6)2]）的晶体结构。研究了Ni（II）配合物及其配体对灰霉病菌、木霉、黑霉菌和黄萎病菌的抑菌活性。实验结果表明，该配体及其配合物具有抗真菌能力。当氟取代对苯甲酰部分时，配体的抗真菌活性明显增强。此外，配体对真菌活性的抑制作用强于它们的配合物。HL6的抗真菌能力特别强，与市售杀菌剂氟康唑相似。
Ni(II) complexes with N-2-fluorobenzoylpiperidine-1-carbothioimidate (L2−), N-4-fluorobenzoylpiperidine-1-carbothioimidate (L3−), N-2-fluorobenzoylmorpholine- 1-carbothioimidate (L5−) and N-4-fluorobenzoylmorpholine-1-carbothioimidate (L6−) have been synthesized and characterized by elemental analysis, FTIR and 1H-NMR. The crystal structures of three ligands (HL2, HL3 and HL6) and the corresponding Ni(II) complexes ([Ni(L2)2], [Ni(L3)2] and [Ni(L6)2]) have been determined by X-ray diffraction. The antifungal activities of the Ni(II) complexes together and the corresponding ligands against the fungi Botrytis cinerea, Trichoderma spp., Myrothecium and Verticillium spp. have been investigated. The experimental results showed that the ligands and their complexes have antifungal abilities. When the fluorine was substituted on the para-benzoyl moiety, the antifungal activity of the ligands was obviously increased. Moreover, the ligands were stronger than their complexes in inhibiting fungal activities. The antifungal ability of HL6 is especially strong, and similar to that of the commercial fungicide fluconazole.
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