POSTNATAL-DEVELOPMENT OF MUCOSA-ASSOCIATED LYMPHOID-TISSUES IN CHICKENS
POSTNATAL-DEVELOPMENT OF MUCOSA-ASSOCIATED LYMPHOID-TISSUES IN CHICKENS
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DOI：
10.1007/bf00223151
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发表时间：
1989-10-01
影响因子：
3.6
通讯作者：
DEBOER, GF
中科院分区：
文献类型：
--
作者：
JEURISSEN, SHM;JANSE, EM;DEBOER, GF
鸡的眼睛，肺和肠粘膜相关淋巴组织的出生后发育进行了研究与特异性的单克隆抗体的所有白细胞，B淋巴细胞，单核吞噬细胞，IgM，IgG，或伊加。人们注意到淋巴浸润与周围粘膜的关系，B细胞和T细胞区的分离，生发中心的发育和分泌免疫球蛋白。丰富的分泌IgM和伊加检测到的哈氏腺的上皮细胞在眼眶，即使他们缺乏大的白细胞浸润与生殖中心。肺和肠粘膜中的类淋巴组织形成了独立的B细胞和T细胞区。从12周龄开始，前胃、Meckel憩室和Peyers集合淋巴结通常都含有生发中心，因为2周龄的鸡在支气管相关淋巴组织和盲肠扁桃体中就有生发中心，这些区域可能受到抗原的高度刺激。同种型特异性单克隆抗体被用来检测IgM，IgG，IgA轴承滤泡细胞在同一germination中心。
The postnatal development of chicken mucosa-associated lymphoid tissues of the eyes, lungs, and intestines were investigated with monoclonal antibodies specific for either all leucocytes, B lymphocytes, mononuclear phagocytes, IgM, IgG, or IgA. Attention has been paid to the relation of lymphoid infilrates with their surrounding mucosae, the segregation into B-cell and T-cell areas, development of germinal centers, and secretory immunoglobulins. Abundant secretory IgM and IgA was detected in the epithelium of the Harderian glands in the orbits, even though they lacked large leucocyte inflitrates with germinal centers. Lymphoid tissues in the mucosae of lungs and intestines developed separate B-cell and T-cell areas. The proventriculus, Meckel''s diverticulum, and Peyers patches generally contained germinal centers from 12 weeks of age on. Because chickens as young as 2 weeks old had germinal centers in bronchus-associated lymphoid tissue and cecal tonsils, these areas were probably highly stimulated by antigens. Isotype-specific monoclonal antibodies were used to detect IgM, IgG-, and IgA-bearing follicular cells in the same germinal center.