Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons
Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons
复制标题
DOI：
10.1016/j.expneurol.2004.10.013
复制
发表时间：
2005-03-01
影响因子：
5.3
通讯作者：
Madison, RD
中科院分区：
文献类型：
--
作者：
Robinson, GA;Madison, RD
先前在小鼠和大鼠中使用股神经模型的研究已经表明，再生运动轴突更喜欢将终末神经分支再神经支配到肌肉，而不是将终末神经分支再神经支配到皮肤，这一过程被称为优先运动神经再支配（PMR）。如果终末器官与肌肉和皮肤的接触被阻止，这种优先的运动神经再支配仍然发生在大鼠中。为了更好地了解优先运动神经再支配的过程中，小鼠，我们研究了运动神经元的肌肉和皮肤通路的神经再支配没有任何终末器官接触，以及只有皮肤终末器官接触。令人惊讶的是，没有优先的运动reirmervation：运动神经元更喜欢皮肤通路的肌肉通路时，所有的终末器官接触被阻止，并表现出更大的偏好皮肤通路时，它附着在皮肤上。(C)2004年爱思唯尔公司All rights reserved.
Previous studies using the femoral nerve model in both mice and rats have shown that regenerating motor axons prefer to reinnervate the terminal nerve branch to muscle versus a terminal nerve branch to skin, a process that has been termed preferential motor reinnervation (PMR). If end organ contact with muscle and skin is prevented, this preferential motor reinnervation still occurs in the rat. To better understand the process of preferential motor reinnervation in the mouse, we examined motor neuron reinnervation of muscle and cutaneous pathways without any end organ contact as well as with only cutaneous end organ contact. Surprisingly, there was no preferential motor reirmervation: Motor neurons preferred the cutaneous pathway over the muscle pathway when all end organ contact was prevented and showed an even greater preference for the cutaneous pathway when it was attached to skin. (C) 2004 Elsevier Inc. All rights reserved.