Inflammatory Response after Implantation of a Left Ventricular Assist Device: Comparison between the Axial Flow MicroMed DeBakey VAD and the Pulsatile Novacor Device
Inflammatory Response after Implantation of a Left Ventricular Assist Device: Comparison between the Axial Flow MicroMed DeBakey VAD and the Pulsatile Novacor Device
复制标题
植入左心室辅助装置后的炎症反应：轴流 MicroMed DeBakey VAD 与脉动 Novacor 装置之间的比较
DOI：
--
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
R. Hetzer
中科院分区：
文献类型：
--
作者：
M. Loebe;A. Koster;S. Sänger;E. Potapov;H. Kuppe;G. Noon;R. Hetzer
心室辅助装置（VAD）的植入与炎症系统的刺激有关。我们比较了植入脉冲式Novacor左（L）VAD和轴流式MicroMed DeBakey VAD后炎症反应的变化。研究纳入了6例植入Novacor LVAD（NC）后的连续患者和6例植入MicroMed DeBakey VAD（MD）后的患者。患者接受LVAD治疗医学上无法治疗的终末期心力衰竭。在植入器械后3个月内，每周两次测量肿瘤坏死因子α（TNF）、C3 a、C5 a、白细胞介素6（IL-6）和中性粒细胞弹性蛋白酶。所有试验均采用酶联免疫吸附试验进行。两组的临床病程无显著差异。在整个研究期间，两组的所有炎症参数均升高。两组之间的TNF、多核白细胞弹性蛋白酶或C3 a水平没有差异;但是，植入轴流式MicroMed DeBakey VAD后，患者的IL-6（NC：23.6 ± 37.6 pg/ml vs. MD：63 ± 114 pg/ml，p < 0.001）和C5 a（NC：708 ± 352 g/L vs. MD：1，745 ± 1，305 g/L，p < 0.001）显著增加。与脉动Novacor装置相比，轴流式MicroMed DeBakey LVAD的植入似乎与炎症系统的一部分的刺激增加有关。进一步的研究是必要的，以评估这些发现的病理生理机制和临床意义。
The implantation of a ventricular assist device (VAD) is associated with a stimulation of the inflammatory system. We compared changes in the inflammatory response after implantation of a pulsatile Novacor left (L) VAD and the axial flow MicroMed DeBakey VAD. Six consecutive patients after implantation of a Novacor LVAD (NC) and six patients after implantation of a MicroMed DeBakey VAD (MD) were included in the investigation. Patients received LVADs for medically non treatable end-stage heart failure. Tumor necrosis factor alpha (TNF), C3a, C5a, interleukin 6 (IL-6), and neutrophil elastase were measured twice a week over a period of 3 months after implantation of the device. All tests were performed with an enzyme-linked immunosorbent assay. There was no significant difference in the clinical course of the two groups. All inflammatory parameters were elevated in both groups during the entire period of the investigation. There was no difference in TNF, polynuclear leukocyte elastase, or C3a levels between the two groups; however, IL-6 (NC: 23.6 ± 37.6 pg/ml vs. MD: 63 ± 114 pg/ml, p < 0.001) and C5a (NC: 708 ± 352 &mgr;g/L vs. MD: 1,745 ± 1,305 &mgr;g/L, p < 0.001) were increased significantly more in patients following implantation of the axial flow MicroMed DeBakey VAD. Compared with the pulsatile Novacor device, the implantation of the axial flow MicroMed DeBakey LVAD seems to be associated with an increased stimulation of one part of the inflammatory system. Further investigations are necessary for evaluation of the pathophysiologic mechanism and clinical implications of these findings.
接受白细胞介素 6 作为细胞因子治疗的患者血小板功能的改变。
影响因子：
2.4
作者：
Oleksowicz,L;Puszkin,E;Mrowiec,Z;Isaacs,R;Dutcher,JP
通讯作者：
Dutcher,JP
影响因子：
20.3
作者：
Jansen, PM;Pixley, RA;Colman, RW
通讯作者：
Colman, RW