A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
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一种逆转录病毒致癌基因 akt，编码含有 SH2 样区域的丝氨酸-苏氨酸激酶。
DOI：
10.1126/science.254.5029.274
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Tsichlis,PN
中科院分区：
文献类型：
--
作者：
Bellacosa,A;Testa,JR;Staal,SP;Tsichlis,PN
v-aktoncogene编码105千道尔顿的融合磷蛋白，在其氨基末端含有Gag序列。v-akt的序列分析及其产物的生物化学表征显示，它编码蛋白激酶C相关的丝氨酸-苏氨酸激酶，其细胞同源物在大多数组织中表达，在胸腺中发现的量最高。虽然Akt是一种丝氨酸-苏氨酸激酶，但其调控区的一部分与Src同源性-2结构域相似，Src同源性-2结构域是在蛋白质-蛋白质相互作用中起作用的细胞质酪氨酸激酶的结构基序特征。这表明Akt可能在酪氨酸和丝氨酸-苏氨酸磷酸化途径之间形成功能性联系。
The v-aktoncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-aktand biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.