Comparison of User-Directed and Automatic Mapping of the Planned Isocenter to Treatment Space for Prostate IGRT.
Comparison of User-Directed and Automatic Mapping of the Planned Isocenter to Treatment Space for Prostate IGRT.
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前列腺 IGRT 的计划等中心点与治疗空间的用户引导和自动映射的比较。
DOI：
10.1155/2013/892152
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发表时间：
2013
影响因子：
7.6
通讯作者：
Chaney,Edward
中科院分区：
文献类型：
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作者：
Xu,Zijie;Chen,Ronald;Wang,Andrew;Kress,Andrea;Foskey,Mark;Qin,An;Cullip,Timothy;Tracton,Gregg;Chang,Sha;Tepper,Joel;Yan,Di;Chaney,Edward
图像引导放射治疗（IGRT）、自适应放射治疗（ART）和在线再优化依赖于从规划到治疗空间的放射束等中心的精确映射。这种映射包括规划（pCT）和治疗内（tCT） CT图像的刚性和/或非刚性配准。本研究的目的是回顾性比较全自动方法（包括非刚性步骤）与用户指导的刚性方法在前列腺癌临床IGRT方案中的实施。将自动和临床定位产生的等中心点与每个tCT仔细确定的参考等中心点进行比较。比较基于参考等中心的位移和前列腺剂量-体积直方图（DVHs）。10例患者共243例tct被调查。发现全自动登记与临床方案一样准确，但对所有患者更精确。所有图像计算的无符号偏移、y和zoffset的平均值和标准差（σ）分别为（avg±σ(mm)）：临床方案为1.1±1.4、1.8±2.3、2.5±3.5，自动方法为0.6±0.8、1.1±1.5和1.1±1.4。自动作图没有失败或异常值，而临床方案出现了8个异常值。
Image‐guided radiotherapy (IGRT), adaptive radiotherapy (ART), and online reoptimization rely on accurate mapping of the radiation beam isocenter(s) from planning to treatment space. This mapping involves rigid and/or nonrigid registration of planning (pCT) and intratreatment (tCT) CT images. The purpose of this study was to retrospectively compare a fully automatic approach, including a non‐rigid step, against a user‐directed rigid method implemented in a clinical IGRT protocol for prostate cancer. Isocenters resulting from automatic and clinical mappings were compared to reference isocenters carefully determined in each tCT. Comparison was based on displacements from the reference isocenters and prostate dose‐volume histograms (DVHs). Ten patients with a total of 243 tCTs were investigated. Fully automatic registration was found to be as accurate as the clinical protocol but more precise for all patients. The average of the unsignedx, y,andzoffsets and the standard deviations (σ) of the signed offsets computed over all images were (avg. ±σ(mm)): 1.1 ± 1.4, 1.8 ± 2.3, 2.5 ± 3.5 for the clinical protocol and 0.6 ± 0.8, 1.1 ± 1.5 and 1.1 ± 1.4 for the automatic method. No failures or outliers from automatic mapping were observed, while 8 outliers occurred for the clinical protocol.