Central-nervous-system lymphoma related to Epstein-Barr virus.
Central-nervous-system lymphoma related to Epstein-Barr virus.
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DOI：
10.1056/nejm198309293091301
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发表时间：
1983-09
期刊：
影响因子：
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通讯作者：
F. Hochberg;G. Miller;R. Schooley;M. Hirsch;P. Feorino;W. Henle
中科院分区：
文献类型：
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作者：
F. Hochberg;G. Miller;R. Schooley;M. Hirsch;P. Feorino;W. Henle
我们研究了五个病例，表明 Epstein-Barr 病毒感染与中枢神经系统原发性淋巴瘤之间存在关系。一名 48 岁男性患有中枢神经系统原发性淋巴瘤，但没有全身性淋巴瘤或免疫抑制。肿瘤的发展与血清学证据相关，表明最近原发性感染了 Epstein-Barr 病毒。当与由 Epstein-Barr 病毒株 FF41 的 BamHI K 片段组成的探针杂交时，来自肿瘤组织（而非邻近正常脑组织）的 DNA 制剂含有 Epstein-Barr 病毒基因组。对另外四名中枢神经系统淋巴瘤患者的血清样本进行评估，发现了 Epstein-Barr 病毒特异性抗体的模式，提示 EBV 持续感染。我们的结果表明 Epstein-Barr 病毒可诱导淋巴瘤。
We have studied five cases suggesting a relation between Epstein-Barr virus infection and primary lymphoma of the central nervous system. A 48-year-old man had primary lymphoma of the central nervous system in the absence of systemic lymphoma or immunosuppression. Development of the tumor was associated with serologic evidence suggesting a recent primary infection with Epstein-Barr virus. DNA preparations from tumor tissue, but not from adjacent normal brain tissue, contained Epstein-Barr virus genomes when hybridized with a probe consisting of the BamHI K fragment of Epstein-Barr virus strain FF41. Evaluation of serum samples from four additional patients with central-nervous-system lymphoma revealed patterns of Epstein-Barr virus-specific antibody that were suggestive of an ongoing infection with EBV. Our results suggest induction of the lymphoma by Epstein-Barr virus.