Relationship among neuroimaging indices of cerebral health during normal aging
Relationship among neuroimaging indices of cerebral health during normal aging
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DOI：
10.1002/hbm.20369
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发表时间：
2008-01-01
影响因子：
4.8
通讯作者：
Fox, Peter T.
中科院分区：
文献类型：
--
作者：
Kochunov, Peter;Thompson, Paul M.;Fox, Peter T.
大脑衰老的敏感测量对于衡量影响衰老和退化过程的因素（例如风险基因或治疗）显示出巨大的前景。在这里，我们检查了三个脑健康指标的年龄相关趋势：脑回灰质 (GM) 厚度、脑脊液脑沟扩张以及 T2 高信号白质 (HWM) 病变体积。该研究涉及 31 名年龄在 57-82 岁之间的健康成年人。使用高分辨率 3D T1 和 T2 加权脑 MR 图像测量平均 GM 厚度、平均脑沟跨度和 HWM 体积。三个脑健康指数的年龄相关趋势与之前发表的研究结果一致，尽管对其协方差的分析导致了之前未报告的关系。同时多元回归发现，皮质沟的扩张主要（t = 2.59，P < 0.01）与 HWM 体积的增加相关，其次与皮质 GM 厚度的减少相关（t = -2.51，P < 0.01）。 GM 厚度减少与 HWM 体积增加之间的校正相关性并不显着 (P = 0.34)。这些发现对于设计大脑老化的定量测量以监测个体患者和大规模临床试验很有意义。
Sensitive measures of brain aging show great promise for gauging factors that affect aging and degenerative processes, such as risk genes or therapy. Here we examined age-related trends for three indices of cerebral health: gyral gray matter (GM) thickness, dilation of sulcal spaces with CSF, and the volume of T2-hyperintense white matter (HWM) lesions. The study involved 31 healthy adults age 57-82 years old. Measurements of average GM thickness, average sulcal span and HWM volume were performed using high-resolution 3D T1- and T2-weighted brain MR images. Age-related trends for the three cerebral health indices were consistent with previously published work though the analysis of their covariance led to a previously unreported relationship. Simultaneous multiple regression found that dilation of cortical sulci were primarily (t = 2.59, P < 0.01) related to the increases in HWM volume and secondarily related (t = -2.51, P < 0.01) to the reductions of the cortical GM thickness. The are-corrected correlation between reduction in GM thickness and increases in HWM volume, was not significant (P = 0.34). These findings are of interest in designing quantitative measures of brain aging for monitoring individual patients and in large-scale clinical trials.