A unified modeling framework for metabonomic profile development and covariate selection for acute trauma subjects.
A unified modeling framework for metabonomic profile development and covariate selection for acute trauma subjects.
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DOI：
10.1002/sim.3279
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发表时间：
2008-08-30
影响因子：
2
通讯作者：
Dey, D. K.
中科院分区：
文献类型：
--
作者：
Ghosh, S.;Dey, D. K.
急性创伤通常与人类多器官系统的进行性恶化相关，并且是创伤护理单位中死亡的主要原因。以非侵入性方式识别特定器官衰竭以及不同人口统计学因素对急性创伤偶然进展的贡献对于创伤状态的成功诊断、预后或监测至关重要。近年来，电喷雾离子化（ESI）和基质辅助激光解吸（MALDI）飞行时间（TOF）质谱已被用于蛋白质组学和代谢组学研究中的生物标志物鉴定。在这类研究中，质谱仪产生的数据集通常非常大，因此需要使用复杂的统计技术来收集有用的信息。在最近的一项研究中，Ghosh等人提出了一种统一的半参数方法，用于区分创伤受试者组与由正常个体组成的对照组的尿代谢谱。在这项研究中，我们扩展了他们的方法，结合现有的协变量信息，在急性创伤的代谢组学谱的发展。我们已经表明，年龄是一个统计学上显着的协变量在创伤和对照组，从而指出，创伤的预后可能与受试者的年龄密切相关的事实。
Acute trauma is often associated with progressive deterioration of multiple organ systems in humans and is the leading cause of death in trauma care units. Identification of specific organ failure in non-invasive fashion and the contribution of different demographic factors on the casual progression of acute trauma is of supreme interest for successful diagnosis, prognosis or monitoring of trauma status. Recently electrospray ionization (ESI) and matrix assisted laser desorption (MALDI) time-of-flight (TOF) mass spectrometry have been used to identify biomarkers both in Proteomics and Metabonomics studies. Data sets generated from mass spectrometers in such studies are generally very large in size and thus require the use of sophisticated statistical techniques to glean useful information. In a recent development Ghosh et al. suggested a unified semi-parametric approach to distinguish urinary metabolic profiles in a group of traumatic subjects from those of a control group consisting of normal individuals. In this study we have extended their approach by combining available covariate information in the development of metabonomic profile of acute trauma. We have shown that age is a statistically significant covariate across trauma and control group, thus pointing out the fact that prognosis of trauma may be acutely linked with subjects age.
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