The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults.
The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults.
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中国老年人的红细胞脂肪酸谱和认知功能
DOI：
10.3390/nu8070385
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发表时间：
2016-06-23
期刊：
影响因子：
5.9
通讯作者：
Xiao R
中科院分区：
文献类型：
--
作者：
Yuan L;Zhen J;Ma W;Cai C;Huang X;Xiao R
目的：探讨中国老年人群红细胞脂肪酸谱与认知之间的关系。方法：60名轻度认知障碍（MCI）受试者和60名年龄及性别匹配的对照成年人（年龄55岁及以上）参与了这项横断面研究。使用蒙特利尔认知评估（MoCA）测试来测量认知功能。通过问卷调查收集参与者的人口统计学特征和生活方式信息。采用半定量食物频率问卷（FFQ）法进行饮食评估。测量红细胞脂肪酸谱。结果：MCI受试者的教育水平低于对照受试者（p < 0.05）。与对照受试者相比，MCI受试者每日家禽摄入量较高，鱼类摄入量较低（p < 0.05）。与对照受试者相比，MCI受试者红细胞脂肪酸谱的特点是20:4 n - 6、20:5 n - 3和总n - 3脂肪酸的红细胞比例较低（p < 0.05）。检测到18:0、22:0、总饱和脂肪酸（SFA）、18:2 n - 6、24:4 n - 6脂肪酸、二十二碳六烯酸（DHA）和总n - 6多不饱和脂肪酸（PUFAs）的红细胞比例与中国老年人群的认知有关。结论：红细胞脂肪酸谱与老年人的认知有关。红细胞不饱和脂肪酸比例较低和饱和脂肪酸比例较高可能预示着中国老年人群认知功能下降。
Objective: To explore the relationship between the erythrocyte fatty acid profile and cognition in elderly Chinese adults. Methods: 60 mild cognitive impairment (MCI) subjects and 60 age- and gender-matched control adults (aged 55 years and above) were involved in this cross-sectional study. Cognitive function was measured by using the Montreal Cognitive Assessment (MoCA) test. Information regarding the demographic characteristics and lifestyle of the participants was collected with a questionnaire. A semi-quantified food frequency questionnaire (FFQ) method was used for dietary assessment. The erythrocytes fatty acid profile was measured. Results: The MCI subjects had a lower education level than the control subjects (p < 0.05). Compared with control subjects, MCI subjects had higher daily poultry intake and lower fish intake (p < 0.05). Erythrocyte fatty acid profile of the MCI subjects was characterized as lower erythrocyte proportions of 20:4 n-6, 20:5 n-3, and total n-3 fatty acids compared with control subjects (p < 0.05). An association of erythrocyte proportions of 18:0, 22:0, total SFA, 18:2 n-6, 24:4 n-6 fatty acids, docosahexaenoic acid (DHA), and total n-6 PUFAs with cognition in elderly Chinese adults was detected. Conclusion: The erythrocyte fatty acid profile was related to cognitionin the elderly. Lower erythrocyte unsaturated fatty acid and higher saturated fatty acid proportions might predict cognitive function decline in elderly Chinese adults.