THE EFFECT OF ANTI‐INTERLEUKIN-2 RECEPTOR MONOCLONAL ANTIBODY ON ALLOGRAFT REJECTION
THE EFFECT OF ANTI‐INTERLEUKIN-2 RECEPTOR MONOCLONAL ANTIBODY ON ALLOGRAFT REJECTION
复制标题
抗白细胞介素2受体单克隆抗体对同种异体移植排斥的影响
DOI：
10.1097/00007890-198512000-00029
复制
发表时间：
1985
期刊：
影响因子：
6.2
通讯作者：
T. Strom
中科院分区：
文献类型：
--
作者：
R. Kirkman;L. V. Barrett;G. Gaulton;V. Kelley;W. Koltun;F. J. Schoen;A. Ythier;T. Strom
在对同种异体移植物的免疫应答期间，活化的T细胞表达许多细胞表面活化抗原，其中包括淋巴因子白细胞介素2（IL-2）的膜受体。由于IL-2受体不存在于静息T细胞上，因此它为潜在的特异性免疫抑制治疗提供了一个有吸引力的靶点。研究了与鼠IL-2受体结合的大鼠单克隆抗体M7/20对近交系小鼠中两种H-2不相容品系组合的同种异体移植物存活的影响。用M7/20处理10天，在两种品系组合中显著延长了血管化的异位心脏同种异体移植物的存活率，50%的受体移植物存活不确定。在两种组合中的一种中，相同的治疗显著延长了皮肤移植物的存活。这些结果支持了IL-2受体在移植排斥机制中的重要作用，并证实了其作为移植免疫抑制治疗靶点的适用性。
During immune response to an allograft, activated T cells express a number of cell surface activation antigens, among them the membrane receptor for the lymphokine interleukin 2 (IL-2). As the IL-2 receptor is not present on resting T cells, it offers an attractive target for potentially specific immunosuppressive therapy. The rat monoclonal antibody M7/20, which binds to the murine IL-2 receptor, was studied for its effect on allograft survival in two H-2-incompatible strain combinations in inbred mice. Treatment with M7/20 for 10 days markedly prolonged survival of vascularized, hetero topic heart allografts in both strain combinations, with indefinite graft survival in 50% of recipients. The same treatment significantly prolonged skin allograft survival in one of the two combinations. The results support the important role of the IL-2 receptor in the mechanism of graft rejection and confirm its suitability as a target for immunosuppressive therapy in transplantation.