Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based study.
Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based study.
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中华人民共和国山西省的人乳头瘤病毒感染：一项基于人群的研究。
DOI：
10.1038/sj.bjc.6603208
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发表时间：
2006-07-03
影响因子：
8.8
通讯作者：
Franceschi, S
中科院分区：
文献类型：
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作者：
Dai, M;Bao, Y P;Li, N;Clifford, G M;Vaccarella, S;Snijders, P J F;Huang, R D;Sun, L X;Meijer, C J L M;Qiao, Y L;Franceschi, S
为了解宫颈癌死亡率较高的山西省中国农村地区宫颈感染的情况及其危险因素，我们对662名15~59岁的妇女进行了宫颈细胞标本的访谈和采集。使用基于GP5+/6+的聚合酶链式反应方法共鉴定出24种不同的HPV类型，能够检测出44种不同的HPV类型。在没有宫颈异常的妇女中，人类乳头瘤病毒的总流行率为14.8%，在没有宫颈异常的妇女中为9.6%(按照世界标准人口的年龄标准，分别为14.2和8.9%)。多型感染占感染总数的30.6%。到目前为止，最常见的类型是HPV16型(占所有女性的5.7%，HPV阳性女性的38.8%)，其次是HPV58、52、33和18。与之前发表的大多数研究不同，35岁以下女性的HPV感染率(8.7%)低于35岁以上女性的患病率(17.8%)。高危型HPV型在所有年龄组中占主导地位。尽管低危HPV类型在年轻女性中很少见，但随着年龄的增长，它们变得越来越常见。宫颈上皮内瘤变3级患者中92.3%感染高危型HPV，无一例仅感染低危型。在这一中国农村低收入人群中，受教育程度、性行为习惯、生育史和避孕方法的使用等因素对HPV阳性的影响无显著差异。
To investigate the prevalence of, and risk factors for, cervical infection with human papillomavirus (HPV) in the rural province of Shanxi, People's Republic of China, which has relatively high cervical cancer mortality rates, we interviewed and obtained cervical cell samples from 662 women aged 15–59 years. A total of 24 different HPV types were identified using a GP5+/6+-based PCR assay able to detect 44 different HPV types. Human papillomavirus prevalence was 14.8% overall and 9.6% among women without cervical abnormalities (14.2 and 8.9%, respectively, age standardised to the world standard population). Multiple-type infections accounted for 30.6% of all infections. By far the most commonly found type was HPV16 (5.7% of all women and 38.8% of HPV-positive women), followed by HPV 58, 52, 33 and 18. Unlike most previous studies published, HPV prevalence was lower among women younger than 35 years (8.7%) than those older than 35 years (17.8%). High-risk HPV types predominated in all age groups. Although low-risk HPV types were rare in young women, they became more common with increasing age. 92.3% of women with cervical intraepithelial neoplasia grade 3 were infected with high-risk HPV types, but none with low-risk types only. No significant difference in HPV positivity was observed by educational level, sexual habits, reproductive history or use of contraceptive methods in this rural low-income Chinese population.