Molecular components of striatal plasticity: the various routes of cyclic AMP pathways.
Molecular components of striatal plasticity: the various routes of cyclic AMP pathways.
复制标题
纹状体可塑性的分子成分：环 AMP 途径的各种途径。
DOI：
10.1159/000017314
复制
发表时间：
1998
影响因子：
2.9
通讯作者：
Konradi,C
中科院分区：
文献类型：
--
作者：
Rajadhyaksha,A;Leveque,J;Macías,W;Barczak,A;Konradi,C
Neuroplasticity serves an important role for normal striatal function and in disease states. One route to neuroplasticity involves activation of the transcription factor cyclic 3′,5′-adenosine monophosphate (cyclic AMP) response element binding protein (CREB) by phosphorylation of the amino acid133Ser. Dopamine and glutamate, the two predominant neurotransmitters in the striatum, induce CREB phosphorylation in primary cultures of rat striatum through cyclic AMP and Ca2+pathways. Here we present the role of N-methyl-D-aspartate receptors and Ca2+in cyclic AMP-mediated CREB phosphorylation.
