Models of mild traumatic brain injury: translation of physiological and anatomic injury.
Models of mild traumatic brain injury: translation of physiological and anatomic injury.
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DOI：
10.1227/neu.0000000000000472
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发表时间：
2014-10-01
期刊：
影响因子：
4.8
通讯作者：
Bailes, Julian E
中科院分区：
文献类型：
--
作者：
Petraglia, Anthony L;Dashnaw, Matthew L;Bailes, Julian E
轻型创伤性脑损伤(TBI)已成为一种日益流行的疾病，每年影响数百万人。尽管这是最常见的脑损伤类型，但我们对轻度脑损伤背后的科学认识还处于初级阶段。随着新的临床证据表明脑震荡和亚脑震荡可能导致有害的长期神经后遗症，特别是当反复发生时，人们对轻度脑外伤的基础科学研究兴趣激增。许多动物模型被用来研究脑外伤的不同病理机制，最近在实验室中也高度重视对轻度脑损伤的模拟。尽管仍有更多的工作要做，但最广泛使用的脑损伤模型已经被应用于实验性的轻度脑损伤研究。为脑震荡创造改进的诊断方法和治疗方法的能力取决于临床上相关的轻度脑损伤模型的发展和特征。这篇综述旨在提供一个广泛的概括性综述，概述目前在动物身上模拟轻度脑外伤的努力，以及将这种行为、生理和解剖学知识从实验台转化到临床领域所存在的挑战和限制。
Mild traumatic brain injury (TBI) has become a rising epidemic, affecting millions of people each year. Even though it is the most common type of brain injury, our understanding of the science underlying mild TBI is just in its infancy. There has been an explosion of basic science research interest in mild TBI, as emerging clinical evidence is suggestive that concussion and subconcussion may result in detrimental long-term neurological sequelae, particularly when occurring repetitively. Many animal models have been developed to study the different pathological mechanisms implicated in TBI, and more recently there has been a heightened focus on modeling mild TBI in the laboratory as well. The most widely used models of TBI have been adapted for experimental mild TBI research, although more work still remains. The ability to create improved diagnostic measures and treatment approaches for concussion depend on the development and characterization of clinically relevant models of mild TBI. This review aims to provide a broad general overview of the current efforts to model mild TBI in animals and the challenges and limitations that exist in translating this behavioral, physiological, and anatomic knowledge from the bench to the clinical arena.