The reversal of myelofibrosis associated with chronic myelogenous leukemia after allogeneic bone marrow transplantation.
The reversal of myelofibrosis associated with chronic myelogenous leukemia after allogeneic bone marrow transplantation.
复制标题
同种异体骨髓移植后与慢性粒细胞白血病相关的骨髓纤维化的逆转。
作者：
D. Oblon;G. Elfenbein;R. Braylan;J. Jones;R. Weiner
A 20-year-old male with chronic myelogenous leukemia (CML) and severe bone marrow fibrosis underwent splenectomy, then ablative chemotherapy, followed by bone marrow transplantation from a histocompatible sister. The myelofibrosis completely resolved. Prompt marrow engraftment and disappearance of Philadelphia chromosome positive cells were documented. Therefore, the presence of marrow fibrosis which frequently accompanies CML is rapidly reversible following high dose chemotherapy and is not indicative of a hostile microenvironment which could preclude marrow transplantation for patients with CML and myelofibrosis.
