Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity
Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity
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DOI：
10.1523/jneurosci.5582-05.2006
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发表时间：
2006-05-31
影响因子：
5.3
通讯作者：
Disterhoft, John F.
中科院分区：
文献类型：
--
作者：
Galvez, Roberto;Weiss, Craig;Disterhoft, John F.
胡须偏转条件刺激（CS）被证明激活生理和解剖定义的桶在对侧体感皮层和支持跟踪眨眼条件反应时，配对角膜喷气非条件刺激在兔。细胞色素氧化酶染色的体感须相关的皮质桶分析显示，行特定的扩展相比，nontrained半球的条件。这种扩张是不明显的假条件兔，这表明这种扩张的条件皮质桶在响应一个海马和前脑依赖的学习任务（跟踪条件）是关联的，而不是活动依赖。使用胡须刺激作为CS在研究良好的眨眼条件反射范式将有助于表征感觉皮层参与控制和调节在神经系统和细胞水平的联想学习反应。
Whisker deflection conditioned stimuli ( CS) were demonstrated to activate physiologically and anatomically defined barrels in the contralateral somatosensory cortex and to support trace-eyeblink conditioned responses when paired with corneal airpuff unconditioned stimuli in rabbits. Analysis of cytochrome-oxidase-stained somatosensory whisker-associated cortical barrels revealed a row-specific expansion of the conditioned compared with the nontrained hemisphere. This expansion was not evident in pseudo-conditioned rabbits, suggesting that this expansion of conditioned cortical barrels in response to a hippocampal-and forebrain-dependent learning task ( trace conditioning) is associative rather than activity dependent. Using whisker stimulation as a CS in the well studied eyeblink conditioning paradigm will facilitate characterizing sensory cortical involvement in controlling and modulating an associatively learned response at the neural systems and cellular level.