High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer.
High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer.
复制标题
PD-L1 高表达与 870 名中国乳腺癌患者预后不良相关
DOI：
10.18632/oncotarget.5583
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发表时间：
2015-10-20
期刊：
影响因子：
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通讯作者：
Wang SS
中科院分区：
文献类型：
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作者：
Qin T;Zeng YD;Qin G;Xu F;Lu JB;Fang WF;Xue C;Zhan JH;Zhang XK;Zheng QF;Peng RJ;Yuan ZY;Zhang L;Wang SS
目的探讨PD-L1表达与乳腺癌复发转移的关系。方法收集870例乳腺癌患者的乳腺组织标本。石蜡包埋的肿瘤切片用PD-L1抗体染色。分析PD-L1表达与临床特征、ER/PR/HER 2状态及生存参数的相关性。采用Kaplan-Meier和单变量考克斯比例风险模型分析比较PD-L1高表达患者和无PD-L1表达患者的生存期。结果随访时间17-265个月，中位98个月。PD-L1在乳腺癌中的阳性表达率为21.7%（189/870）。PD-L1高表达与肿瘤大小、肿瘤分级、淋巴结阳性数、ER和PR阴性呈负相关。与非TNBC相比，TNBC中的PD-L1表达特别高，但未观察到统计学显著性。基于临床和病理特征的诺模图logistic回归结果显示，以下因素更可能与PD-L1高表达相关：患者年龄小于35岁，肿瘤大小较大，淋巴血管浸润和晚期。我们的数据表明，PD-L1高表达的患者与PD-L1无表达的患者相比，DFS、DMFS和总生存率较差。单因素考克斯比例风险模型分析显示PD-L1是影响肿瘤预后的独立预后因素。结论PD-L1表达是乳腺癌患者预后不良的重要指标。
Background To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. Methods Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations between PD-L1 expression and clinical characteristics, ER/PR/HER2 status and survival parameters were analyzed. Kaplan-Meier and univariate Cox proportional hazards model analyses were used to compare the survival of patients with high PD-L1 expression and patients with no PD-L1 expression. Results The median follow-up time was 98 months(range, 17–265 months). The positive rate of PD-L1 expression in breast cancer was 21.7% (189/870). PD-L1 high expression was inversely associated with larger tumor size, higher tumor grade, more positive lymph node number, as well as negative ER and PR status. PD-L1 expression was particularly higher in TNBC compared with non-TNBC, although no statistical significance was observed. Nomogram logistic regression results based on clinical and pathological features showed that the following factors were more likely associated with high PD-L1 expression: patient age younger than 35 years, larger tumor size, lymphovascular invasion and advanced stage. Our data indicated that patients with high PD-L1 expression had poor DFS, DMFS and overall survival compared with those with no PD-L1 expression. Univariate Cox proportional hazards model analysis showed that PD-L1 was an independent prognostic factor for tumor prognosis. Conclusions PD-L1 expression is an important indicator of unfavorable prognosis in breast cancer patients.