Plasma Inflammatory Cytokine IL-4, IL-8, IL-10, and TNF-α Levels Correlate with Pulmonary Function in Patients with Asthma-Chronic Obstructive Pulmonary Disease (COPD) Overlap Syndrome.
Plasma Inflammatory Cytokine IL-4, IL-8, IL-10, and TNF-α Levels Correlate with Pulmonary Function in Patients with Asthma-Chronic Obstructive Pulmonary Disease (COPD) Overlap Syndrome.
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DOI：
10.12659/msm.896458
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发表时间：
2016-08-09
期刊：
影响因子：
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通讯作者：
Huang M
中科院分区：
文献类型：
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作者：
Huang AX;Lu LW;Liu WJ;Huang M
本研究旨在探讨哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）患者血浆炎症细胞因子水平及其与肺功能的相关性。2013年1月至2014年12月，共纳入96例哮喘、慢性阻塞性肺疾病急性加重（AECOPD）或ACOS患者，并纳入35名健康人作为对照组。采用酶联免疫吸附试验（ELISA）检测空腹血浆白细胞介素(IL)-4、IL-8、IL-10和肿瘤坏死因子α (TNF-α)水平。分析血浆炎性细胞因子水平与1秒用力呼气量（FEV1）、FEV1/预测值比（FEV1%pred）、FEV1/用力肺活量（FVC）的相关性。三组患者IL-4、IL-8水平差异均有统计学意义（P均<0.001）；AECOPD组和ACOS组IL-4水平显著低于哮喘组，IL-8水平显著高于哮喘组（均P<0.05）。3组患者IL-10、TNF-α水平比较，差异均有统计学意义（P<0.001）。两组患者IL-10水平差异有统计学意义（均P<0.001）。哮喘组TNF-α水平高于AECOPD组和ACOS组（P均<0.001）。IL-4、IL-10与FEV1、FEV1 1%pred、FEV1/FVC呈显著正相关，IL-8、TNF-α呈显著负相关。血浆炎症因子IL-4、IL-8、IL-10和TNF-α水平与气道疾病的严重程度相关，可能是评估哮喘、COPD和ACOS的潜在标志物。
The aim of this study was to investigate the plasma inflammatory cytokine levels and their correlations with pulmonary function in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Between January 2013 and December 2014, a total of 96 patients with asthma, acute exacerbation of chronic obstructive pulmonary disease (AECOPD), or ACOS were enrolled, and 35 healthy people were included as a control group. Fasting plasma interleukin (IL)-4, IL-8, IL-10, and tumor necrosis factor alpha (TNF-α) levels were detected using enzyme-linked immunosorbent assay (ELISA). Correlations between the plasma inflammatory cytokine levels and forced expiratory volume in 1 second (FEV1), FEV1/predicted value ratio (FEV1%pred), and FEV1/forced vital capacity (FVC) were analyzed. IL-4 and IL-8 levels showed statistically significant differences among the 3 groups of patients (both P<0.001); IL-4 level was significantly lower, while IL-8 level was significantly higher in the AECOPD group and ACOS group than those in the asthma group (all P<0.05). IL-10 level and TNF-α level were significantly different among the 3 patient groups (both P<0.001). IL-10 level was significantly different between each of the 2 groups (all P<0.001). TNF-α level in the asthma group was higher than in the AECOPD group and ACOS group (both P<0.001). IL-4 and IL-10 were positively and IL-8 and TNF-α were negatively related with FEV1, FEV1%pred, and FEV1/FVC. Plasma levels of inflammatory cytokines IL-4, IL-8, IL-10, and TNF-α are related with severity of airway diseases and could be potential markers for the evaluation of asthma, COPD, and ACOS.