Cellular entry of thyroid hormones by organic anion transporting polypeptides
Cellular entry of thyroid hormones by organic anion transporting polypeptides
复制标题
DOI：
10.1016/j.beem.2007.03.004
复制
发表时间：
2007-06-01
影响因子：
7.4
通讯作者：
Hagenbuch, Bruno
中科院分区：
文献类型：
--
作者：
Hagenbuch, Bruno
已经鉴定了几个可以转运甲状腺激素的转运蛋白家族。有机阴离子转运多肽（OATP）基因超家族是其中之一，该基因超家族属于溶质载体家族SLCO。在人类中，11种不同的OATP在各种组织中表达，包括肝、肾、脑、肺、肠和胎盘。它们介导多种两亲性有机化合物的钠非依赖性转运，所述两亲性有机化合物包括甲状腺激素、胆汁酸、类固醇激素及其缀合物、线性和环状肽、甘草素、多种药物和其它异生物质。OATP 1 OC 1在血脑屏障和睾丸中表达，是具有最高表观亲和力的甲状腺激素转运蛋白，甲状腺素（T-4）的Km值为90.4 nM，反向T-3（rT（3））转运的Km值为127.7 nM，可能是甲状腺激素向发育中的大脑转运所必需的。OATP 4A 1在胎盘中表达，可能对母体甲状腺激素转运到发育中的胎儿很重要。
Several transporter families that can transport thyroid hormones have been identified. One of these is represented by the organic anion transporting polypeptide (OATP) gene superfamily, classified within the solute carrier family SLCO. In humans, eleven different OATPs are expressed in various tissues, including the liver, kidney, brain, lung, intestine and placenta. They mediate sodium-independent transport of a variety of amphipathic organic compounds, including thyroid hormones, bile acids, steroid hormones and their conjugates, linear and cyclic pepticles, prostaglandins, numerous drugs and other xenobiotics. OATP1OC1, which is expressed in the blood-brain barrier and testes, is the thyroid hormone transporter with the highest apparent affinity, with K-m values of 90.4 nM for thyroxine (T-4) and 127.7 nM for reverse T-3 (rT(3)) transport, and could be essential for thyroid hormone delivery to the developing brain. OATP4A1 is expressed in the placenta and could be important for maternal thyroid hormone transport to the developing fetus.